RFX3
| Gene Symbol | RFX3 |
|---|---|
| Entrez Gene | 5991 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | regulatory factor X, 3 (influences HLA class II expression) |
| Other Description | DNA binding protein RFX3|transcription factor RFX3 |
| Swissprots | Q95HL5 D3DRH9 Q5JTL7 Q6NW13 Q95HL6 D3DRH8 Q5JTL8 Q8WTU4 P48380 A8K0H5 |
| Accessions | EAW58794 EAW58795 EAW58796 EAW58797 EAW58798 EAW58799 P48380 AI811824 AK127804 AK289540 BAF82229 AK310956 AW152407 BC022191 AAH22191 BC067778 AAH67778 BM666287 BU170404 DB036180 DB461398 X76092 CAA53706 XM_006716840 XP_006716903 XM_006716842 XP_006716905 XM_006716843 XP_006716906 XM_006716844 XP_006716907 XM_006716845 XP_006716908 XM_006716847 XP_006716910 XM_011517998 XP_011516300 XM_011517999 XP_011516301 XM_011518000 XP_011516302 XM_011518001 XP_011516303 NM_001282116 NP_001269045 NM_001282117 NP_001269046 NM_002919 NP_002910 NM_134428 NP_602304 |
| Function | Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Acts as a transcription factor. Represses transcription of MAP1A in non-neuronal cells but not in neuronal c |
| Subcellular Location | Nucleus {ECO:0000305}. |
RFX3 CRISPR/Cas9 KO Plasmid (h) - sc-407046 from Santa Cruz Biotechnology
|
||||||||
RFX3 HDR Plasmid (h) - sc-407046-HDR from Santa Cruz Biotechnology
|
||||||||
RFX3 Double Nickase Plasmid (h) - sc-407046-NIC from Santa Cruz Biotechnology
|
||||||||
RFX3 Double Nickase Plasmid (h2) - sc-407046-NIC-2 from Santa Cruz Biotechnology
|
||||||||
RFX3 CRISPR Activation Plasmid (h) - sc-407046-ACT from Santa Cruz Biotechnology
|
||||||||
RFX3 CRISPR Activation Plasmid (h2) - sc-407046-ACT-2 from Santa Cruz Biotechnology
|
||||||||
RFX3 Lentiviral Activation Particles (h) - sc-407046-LAC from Santa Cruz Biotechnology
|
||||||||
RFX3 Lentiviral Activation Particles (h2) - sc-407046-LAC-2 from Santa Cruz Biotechnology
|
||||||||
RFX3 siRNA (h) - sc-37745 from Santa Cruz Biotechnology
|
||||||||
RFX3 shRNA Plasmid (h) - sc-37745-SH from Santa Cruz Biotechnology
|
||||||||
RFX3 shRNA (h) Lentiviral Particles - sc-37745-V from Santa Cruz Biotechnology
|
||||||||
RFX3 RNAi - H00005991-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU062131 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18186 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18186 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR07452 from Sigma-Aldrich
|
||||||||
RFX3 siRNA (Human) - CRH4059 from Cohesion Biosciences
|
||||||||
RFX3 RNAi - H00005991-R01 from Novus Biologicals
|
||||||||
RFX3 - MBS8239278 from MyBioSource
|
||||||||
shRNA set against Human RFX3 (NM_002919.2) - SHH392412 from Creative biogene
|
||||||||
shRNA set against Human RFX3(NM_002919.2) - SHR169698 from Creative biogene
|
||||||||
shRNA set against Human RFX3(NM_134428.1) - SHR169716 from Creative biogene
|
||||||||
RFX3 shRNA Plasmid (Human) - CHH4059 from Cohesion Biosciences
|
||||||||
RFX3 miRNA 3'UTR clone - MiUTR1H-08762 from Creative biogene
|
||||||||
RFX3 miRNA 3'UTR clone - MiUTR1H-08763 from Creative biogene
|