CHD5

Gene Symbol	CHD5
Entrez Gene	26038
Alt Symbol	CHD-5
Species	Human
Gene Type	protein-coding
Description	chromodomain helicase DNA binding protein 5
Other Description	ATP-dependent helicase CHD5\|chromodomain-helicase-DNA-binding protein 5
Swissprots	Q9UFR9 Q8TDI0 Q7LGH2 O75032 Q5TG89
Accessions	EAW71516 Q8TDI0 AB007913 BAA32289 AF425231 AAL98962 AK091386 BAG52346 AK126012 BAC86391 AK127046 BAC86802 AL110281 CAH56404 AL117491 CAB55959 AL137693 CAH56377 AW005809 BC048142 BC146381 AAI46382 BC148803 AAI48804 NM_015557 NP_056372
Function	Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of f
Subcellular Location	Nucleus {ECO:0000269\|PubMed:21931736, ECO:0000269\|PubMed:23948251}. Note=Associates with heterochromatin. {ECO:0000250}.
Tissue Specificity	Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis. {ECO:0000269\|PubMed:12592387, ECO:0000269\|PubMed:21931736}.

CHD5 (D-10) - sc-271248 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CHD5 (D-10): sc-271248. Western blot analysis of CHD5 expression in mouse brain (A) and mouse cerebellum (B) tissue extracts.

CHD5 (H-185) - sc-68390 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CHD5 (H-185): sc-68390. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

CHD5 (M-182) - sc-68389 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CHD5 (M-182): sc-68389. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

CHD5 (S-15) - sc-68009 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Chromodomain helicase DNA binding protein 5 antibody - ab66516 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Chromodomain helicase DNA binding protein 5 antibody (ab66516) at 1 µg/mlLane 1 : TE 671 (Human Rhabdomyosarcoma) Whole Cell LysateLane 2 : Hela Whole Cell Lysate - Hydroxyurea Treated (48hr, 2uM)Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 4 : Hela Whole Cell Lysate - Bleomycin Treated (20U/ml)Lane 5 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 6 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 7 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 8 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Chromodomain helicase DNA binding protein 5 antibody - ab192373 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Chromodomain helicase DNA binding protein 5 antibody (ab192373) at 1/500 dilutionLane 1 : HEK293T whole cell lysateLane 2 : NIH-3T3 whole cell lysateLane 3 : Rat brain tissue lysate

Anti-Chromodomain helicase DNA binding protein 5 antibody - ab135032 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Chromodomain helicase DNA binding protein 5 antibody (ab135032) at 1/1000 dilutionLane 1 : HeLa cell extractLane 2 : Mouse brain cell extract

Anti-Chromodomain helicase DNA binding protein 5 antibody [EPR6053] - ab124736 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6053

All lanes : Anti-Chromodomain helicase DNA binding protein 5 antibody [EPR6053] (ab124736) at 1/50000 dilutionLane 1 : Human adrenal gland cell lysateLane 2 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Chromodomain helicase DNA binding protein 5 antibody - C-terminal - ab202132 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue labeling Chromodomain helicase DNA binding protein 5 with ab202132 at 1/40.

Anti-CHD5 Antibody (Internal) - LS-C61721 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-CHD5 Antibody - LS-C191588 from LifeSpan Bioscience

Host	Goat
Clonality	Polyclonal

Anti-CHD5 Antibody - LS-C340963 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHD5 Antibody (Internal, clone EPR6053) - LS-C138804 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR6053

Immunofluorescent staining of SH-SY5Y cells using anti-CHD5 antibody.

CHD5 Antibody - 23320002 from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHD5 antibody produced in rabbit - HPA015809 from Sigma-Aldrich

Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-CHD5:<B>Cat. No. HPA015809</B>: Immunohistochemical staining of human rectum shows strong nuclear positivity in glandular cells.

Anti-CHD5 antibody produced in rabbit - SAB4301046 from Sigma-Aldrich

Prices	$230.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CHD5-Antibody-internal-region - AF2571a from Abgent, a WuXi AppTec company

Prices	$325.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

CHD5 antibody, Internal - GTX89091 from GeneTex

Prices	$239.00
Sizes	100 μg
Host	Goat
Clonality	Polyclonal

CHD5 Antibody (OAEB00673) - OAEB00673 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti -CHD5 (Chromodomain-Helicase-DNA-Binding Protein 5, CHD-5, ATP-Dependent HelicaseCHD5, KIAA0444) - 221670 from USBiological Life Science

Host	Rabbit
Clonality	Polyclonal

Anti-Chromodomain Helicase Dna Binding Protein 5 Antibody - AC21-1152 from Abcore

Prices	$359.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-Chromodomain Helicase Dna Binding Protein 5 Antibody (AMCA) - AC21-1152-01 from Abcore

Prices	$495.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-Chromodomain Helicase Dna Binding Protein 5 Antibody (AP) - AC21-1152-02 from Abcore

Prices	$505.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-Chromodomain Helicase Dna Binding Protein 5 Antibody (APC) - AC21-1152-03 from Abcore

Prices	$515.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

Anti-Chromodomain Helicase Dna Binding Protein 5 Antibody (APC-Cy5.5) - AC21-1152-04 from Abcore

Prices	$539.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

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