| Gene Symbol | CHD5 |
|---|---|
| Entrez Gene | 26038 |
| Alt Symbol | CHD-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromodomain helicase DNA binding protein 5 |
| Other Description | ATP-dependent helicase CHD5|chromodomain-helicase-DNA-binding protein 5 |
| Swissprots | Q9UFR9 Q8TDI0 Q7LGH2 O75032 Q5TG89 |
| Accessions | EAW71516 Q8TDI0 AB007913 BAA32289 AF425231 AAL98962 AK091386 BAG52346 AK126012 BAC86391 AK127046 BAC86802 AL110281 CAH56404 AL117491 CAB55959 AL137693 CAH56377 AW005809 BC048142 BC146381 AAI46382 BC148803 AAI48804 NM_015557 NP_056372 |
| Function | Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of f |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:21931736, ECO:0000269|PubMed:23948251}. Note=Associates with heterochromatin. {ECO:0000250}. |
| Tissue Specificity | Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis. {ECO:0000269|PubMed:12592387, ECO:0000269|PubMed:21931736}. |
CHD5 CRISPR/Cas9 KO Plasmid (h) - sc-402429 from Santa Cruz Biotechnology
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CHD5 HDR Plasmid (h) - sc-402429-HDR from Santa Cruz Biotechnology
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CHD5 Double Nickase Plasmid (h) - sc-402429-NIC from Santa Cruz Biotechnology
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CHD5 Double Nickase Plasmid (h2) - sc-402429-NIC-2 from Santa Cruz Biotechnology
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CHD5 CRISPR Activation Plasmid (h) - sc-402429-ACT from Santa Cruz Biotechnology
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CHD5 CRISPR Activation Plasmid (h2) - sc-402429-ACT-2 from Santa Cruz Biotechnology
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CHD5 Lentiviral Activation Particles (h) - sc-402429-LAC from Santa Cruz Biotechnology
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CHD5 Lentiviral Activation Particles (h2) - sc-402429-LAC-2 from Santa Cruz Biotechnology
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CHD5 siRNA (h) - sc-62102 from Santa Cruz Biotechnology
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CHD5 shRNA Plasmid (h) - sc-62102-SH from Santa Cruz Biotechnology
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CHD5 shRNA (h) Lentiviral Particles - sc-62102-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU154021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6045 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6045 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14144 from Sigma-Aldrich
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CHD5 siRNA (Human) - CRH8671 from Cohesion Biosciences
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CHD5 - MBS8236035 from MyBioSource
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shRNA set against Human CHD5 (NM_015557.2) - SHH262877 from Creative biogene
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Human CHD5 siRNA - orb269173 from Biorbyt
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CHD5 shRNA Plasmid (Human) - CHH8671 from Cohesion Biosciences
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CHD5 miRNA 3'UTR clone - MiUTR4H-TG10890 from Creative biogene
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