CHD5

Gene Symbol	CHD5
Entrez Gene	26038
Alt Symbol	CHD-5
Species	Human
Gene Type	protein-coding
Description	chromodomain helicase DNA binding protein 5
Other Description	ATP-dependent helicase CHD5|chromodomain-helicase-DNA-binding protein 5
Swissprots	Q9UFR9 Q8TDI0 Q7LGH2 O75032 Q5TG89
Accessions	EAW71516 Q8TDI0 AB007913 BAA32289 AF425231 AAL98962 AK091386 BAG52346 AK126012 BAC86391 AK127046 BAC86802 AL110281 CAH56404 AL117491 CAB55959 AL137693 CAH56377 AW005809 BC048142 BC146381 AAI46382 BC148803 AAI48804 NM_015557 NP_056372
Function	Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of f
Subcellular Location	Nucleus {ECO:0000269|PubMed:21931736, ECO:0000269|PubMed:23948251}. Note=Associates with heterochromatin. {ECO:0000250}.
Tissue Specificity	Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis. {ECO:0000269|PubMed:12592387, ECO:0000269|PubMed:21931736}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Chromodomain helicase DNA binding protein 5 peptide - ab69729 from Abcam Category Peptide

CHD5 blocking peptide - GTX89091-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Chromodomain Helicase Dna Binding Protein 5 Peptide - AC21-1152-P from Abcore Category Protein Prices $160.00 Sizes 100 µg

CHD5 Peptide - 46-642P from ProSci Category Peptide

CHD5 fusion protein - ag18621 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CHD5 fusion protein - ag18837 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Chromodomain Helicase DNA Binding Protein 5 (CHD5) - RPC211Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

CHD5 Blocking Peptide - CBP2608 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Chromodomain Helicase DNA Binding Protein 5 (CHD5) - RPC211Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Chromodomain-helicase-DNA-binding protein 5(CHD5) ,partial - CSB-YP848409HU CSB-EP848409HU CSB-BP848409HU CSB-MP848409HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CHD5, Peptide - MBS658676 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg

CHD5, Peptide - MBS425716 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

CHD5-Blocking-Peptide-N-Term - BP22011a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHD5 Recombinant Protein (OPCD02192) - OPCD02192 from Aviva Systems Biology Category Protein Source E.coli Species Human

Chromodomain Helicase DNA Binding Protein 5, Recombinant Protein - MBS2030325 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Chromodomain-helicase-DNA-binding protein 5 (CHD5), partial, Recombinant Protein - MBS1332200 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CHD5 peptide - orb218471 from Biorbyt Category Peptide Species Human, Mouse, Rat

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