Gene Symbol | KCNE2 |
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Entrez Gene | 9992 |
Alt Symbol | ATFB4, LQT5, LQT6, MIRP1 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, voltage gated subfamily E regulatory beta subunit 2 |
Other Description | cardiac voltage-gated potassium channel accessory subunit 2|minK-related peptide 1|minK-related peptide-1|minimum potassium ion channel-related peptide 1|potassium channel subunit beta MiRP1|potassium channel subunit, MiRP1|potassium voltage-gated channel subfamily E member 2|potassium voltage-gated channel, Isk-related family, member 2|voltage-gated K+ channel subunit MIRP1 |
Swissprots | Q9Y6J6 A5H1P3 Q52LJ5 D3DSF8 |
Accessions | ABQ01239 EAX09790 EAX09791 Q9Y6J6 AF071002 AAD28086 AF086086 AF302095 AAG13416 BC093892 AAH93892 BC112087 AAI12088 BG221966 DQ192290 ABB00303 NM_172201 NP_751951 |
Function | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen. {ECO:0000269|PubMed:11034315}. |
Top Pathways | Gastric acid secretion |
MiRP1 (H-4) - sc-374667 from Santa Cruz Biotechnology
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MiRP1 (A-17) - sc-31400 from Santa Cruz Biotechnology
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MiRP1 (H-70) - sc-25703 from Santa Cruz Biotechnology
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MiRP1 (C-20) - sc-16350 from Santa Cruz Biotechnology
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Anti-KCNE2 antibody - ab69376 from Abcam
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Anti-KCNE2 antibody - ab169381 from Abcam
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Anti-MIRP1 / KCNE2 Antibody (aa79-107, AP) - LS-C215370 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107, PE) - LS-C215375 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107, Biotin) - LS-C215372 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107, APC) - LS-C215371 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107, Azide-free, HRP) - LS-C215373 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107, FITC) - LS-C215374 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (HRP) - LS-C317592 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (FITC) - LS-C317593 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107) - LS-C322379 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (Biotin) - LS-C318919 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody - LS-C317595 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa79-107) - LS-C159969 from LifeSpan Bioscience
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Anti-MIRP1 / KCNE2 Antibody (aa33-45) IHC-plus™ - LS-B5136 from LifeSpan Bioscience
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MiRP1 Antibody - NBP1-30637 from Novus Biologicals
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MiRP1 Antibody - NBP2-38146 from Novus Biologicals
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MiRP1 Antibody - NBP2-38653 from Novus Biologicals
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MiRP1 Antibody - H00009992-A01 from Novus Biologicals
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MiRP1 Antibody - H00009992-B01 from Novus Biologicals
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KCNE2 Polyclonal Antibody - bs-9930R from Bioss
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