| Gene Symbol |
KCNE2
|
| Entrez Gene |
9992
|
| Alt Symbol |
ATFB4, LQT5, LQT6, MIRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated subfamily E regulatory beta subunit 2
|
| Other Description |
cardiac voltage-gated potassium channel accessory subunit 2|minK-related peptide 1|minK-related peptide-1|minimum potassium ion channel-related peptide 1|potassium channel subunit beta MiRP1|potassium channel subunit, MiRP1|potassium voltage-gated channel subfamily E member 2|potassium voltage-gated channel, Isk-related family, member 2|voltage-gated K+ channel subunit MIRP1
|
| Swissprots |
Q9Y6J6 A5H1P3 Q52LJ5 D3DSF8
|
| Accessions |
ABQ01239 EAX09790 EAX09791 Q9Y6J6 AF071002 AAD28086 AF086086 AF302095 AAG13416 BC093892 AAH93892 BC112087 AAI12088 BG221966 DQ192290 ABB00303 NM_172201 NP_751951
|
| Function |
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen. {ECO:0000269|PubMed:11034315}.
|
| Top Pathways |
Gastric acid secretion
|