KCNE2
| Gene Symbol | KCNE2 |
|---|---|
| Entrez Gene | 9992 |
| Alt Symbol | ATFB4, LQT5, LQT6, MIRP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated subfamily E regulatory beta subunit 2 |
| Other Description | cardiac voltage-gated potassium channel accessory subunit 2|minK-related peptide 1|minK-related peptide-1|minimum potassium ion channel-related peptide 1|potassium channel subunit beta MiRP1|potassium channel subunit, MiRP1|potassium voltage-gated channel subfamily E member 2|potassium voltage-gated channel, Isk-related family, member 2|voltage-gated K+ channel subunit MIRP1 |
| Swissprots | Q9Y6J6 A5H1P3 Q52LJ5 D3DSF8 |
| Accessions | ABQ01239 EAX09790 EAX09791 Q9Y6J6 AF071002 AAD28086 AF086086 AF302095 AAG13416 BC093892 AAH93892 BC112087 AAI12088 BG221966 DQ192290 ABB00303 NM_172201 NP_751951 |
| Function | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen. {ECO:0000269|PubMed:11034315}. |
| Top Pathways | Gastric acid secretion |
MiRP1 CRISPR/Cas9 KO Plasmid (h) - sc-418462 from Santa Cruz Biotechnology
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MiRP1 HDR Plasmid (h) - sc-418462-HDR from Santa Cruz Biotechnology
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MiRP1 Double Nickase Plasmid (h) - sc-418462-NIC from Santa Cruz Biotechnology
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MiRP1 Double Nickase Plasmid (h2) - sc-418462-NIC-2 from Santa Cruz Biotechnology
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MiRP1 CRISPR Activation Plasmid (h) - sc-418462-ACT from Santa Cruz Biotechnology
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MiRP1 CRISPR Activation Plasmid (h2) - sc-418462-ACT-2 from Santa Cruz Biotechnology
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MiRP1 Lentiviral Activation Particles (h) - sc-418462-LAC from Santa Cruz Biotechnology
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MiRP1 Lentiviral Activation Particles (h2) - sc-418462-LAC-2 from Santa Cruz Biotechnology
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MiRP1 siRNA (h) - sc-42509 from Santa Cruz Biotechnology
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MiRP1 shRNA Plasmid (h) - sc-42509-SH from Santa Cruz Biotechnology
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MiRP1 shRNA (h) Lentiviral Particles - sc-42509-V from Santa Cruz Biotechnology
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MiRP1 RNAi - H00009992-R01 from Novus Biologicals
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MISSION® esiRNA - EHU044021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10934 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10934 from Sigma-Aldrich
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KCNE2 siRNA (Human) - CRH6724 from Cohesion Biosciences
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KCNE2, siRNA - MBS8234956 from MyBioSource
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shRNA set against Human KCNE2 (NM_172201.1) - SHH322939 from Creative biogene
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shRNA set against Human KCNE2(NM_172201.1) - SHL189028 from Creative biogene
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Human KCNE2 siRNA - orb267226 from Biorbyt
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KCNE2 shRNA Plasmid (Human) - CHH6724 from Cohesion Biosciences
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KCNE2 miRNA 3'UTR clone - MiUTR1H-05105 from Creative biogene
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