Gene Symbol | PRCP |
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Entrez Gene | 5547 |
Alt Symbol | HUMPCP, PCP |
Species | Human |
Gene Type | protein-coding |
Description | prolylcarboxypeptidase (angiotensinase C) |
Other Description | angiotensinase C|lysosomal Pro-X carboxypeptidase|lysosomal carboxypeptidase C|proline carboxypeptidase|prolylcarboxypeptidase isoform 1 preproprotein |
Swissprots | B3KRK5 P42785 B2R7B7 A8MU24 B5BU34 |
Accessions | EAW75074 EAW75075 EAW75076 P42785 AB451270 BAG70084 AB451397 BAG70211 AK090847 BAG52238 AK091786 BAG52417 AK302386 BAH13692 AK312919 BAG35764 BC001500 AAH01500 BI827978 BX537480 DB461615 DQ893068 ABM83994 DQ896321 ABM87320 L13977 AAA99891 XM_005274093 XP_005274150 NM_005040 NP_005031 NM_199418 NP_955450 |
Function | Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. |
Subcellular Location | Lysosome. |
Tissue Specificity | Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney. |
Top Pathways | Protein digestion and absorption |
PRCP 293T Cell Transient Overexpression Lysate(Denatured) - H00005547-T01 from Acris Antibodies
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PRCP overexpression lysate - LY403704 from Acris Antibodies
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PRCP 293 Cell Lysate - 408217 from ABBIOTEC
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PRCP 293 Cell Lysate - 403190 from ABBIOTEC
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Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Native) - NBL1-14732 from Novus Biologicals
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Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Native) - NBL1-14731 from Novus Biologicals
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Angiotensinase C (h2): 293T Lysate - sc-170413 from Santa Cruz Biotechnology
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PRCP Over-expression Lysate Product - GWB-9F5FD7 from Genway Biotech
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PRCP Over-expression Lysate Product - GWB-117633 from Genway Biotech
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Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured) - H00005547-T01 from Novus Biologicals
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Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured) - H00005547-T02 from Novus Biologicals
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