PRCP

Gene Symbol PRCP
Entrez Gene 5547
Alt Symbol HUMPCP, PCP
Species Human
Gene Type protein-coding
Description prolylcarboxypeptidase (angiotensinase C)
Other Description angiotensinase C|lysosomal Pro-X carboxypeptidase|lysosomal carboxypeptidase C|proline carboxypeptidase|prolylcarboxypeptidase isoform 1 preproprotein
Swissprots B3KRK5 P42785 B2R7B7 A8MU24 B5BU34
Accessions EAW75074 EAW75075 EAW75076 P42785 AB451270 BAG70084 AB451397 BAG70211 AK090847 BAG52238 AK091786 BAG52417 AK302386 BAH13692 AK312919 BAG35764 BC001500 AAH01500 BI827978 BX537480 DB461615 DQ893068 ABM83994 DQ896321 ABM87320 L13977 AAA99891 XM_005274093 XP_005274150 NM_005040 NP_005031 NM_199418 NP_955450
Function Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Subcellular Location Lysosome.
Tissue Specificity Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
Top Pathways Protein digestion and absorption

Angiotensinase C (H-155) - sc-134494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Angiotensinase C (M-160) - sc-134495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Angiotensinase C (T-15) - sc-49272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Angiotensinase C (T-15): sc-49272. Western blot analysis of Angiotensinase C expression in non-transfected 293T: sc-117752 (A), human Angiotensinase C transfected 293T: sc-170413 (B) and HeLa (C) whole cell lysates.

Angiotensinase C (Y-15) - sc-49274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PRCP antibody - ab182757 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling PRCP with ab182757 at 1/20 dilution (left panel). Right panel is treated with the immunogen.

Anti-PRCP antibody - ab177058 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of formalin-fixed paraffin-embedded human lung cancer labeling PRCP with ab177058 at 1/100 dilution showing cytoplasmic staining

Anti-PRCP antibody - ab72942 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-PRCP antibody (ab72942) at 1/500 dilution + human kidney tissue lysate at 25 µgSecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-PRCP antibody - ab167335 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRCP antibody (ab167335) at 1 µg/mlLane 1 : PRCP transfected 293T cell lysateLane 2 : non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-rabbit IgG HRP at 1/2500 dilution

Anti-PRCP antibody - N-terminal - ab171846 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRCP antibody - N-terminal (ab171846) at 1/100 dilutionLane 1 : MDA-MB231 cell lysateLane 2 : HeLa cell lysateLysates/proteins at 35 µg per lane.

Anti-PRCP Antibody (aa114-143, APC) - LS-C267058 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa114-143, AP) - LS-C267057 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa114-143, Biotin) - LS-C267059 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa114-143, FITC) - LS-C267060 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa114-143, Azide-free, HRP) - LS-C267061 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa114-143, PE) - LS-C267062 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa113-350, Biotin) - LS-C298432 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (aa113-350, FITC) - LS-C305282 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRCP Antibody (N-Terminus) - LS-C346036 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PCP Antibody with human Fetal Lung lysate.

Anti-PRCP Antibody (aa113-350) - LS-C296055 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PRCP / PCP.

Anti-PRCP Antibody (aa114-143) - LS-C162119 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PRCP Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PRCP Antibody (aa113-143) - LS-C324273 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Lysosomal Pro-X Carboxypeptidase/PRCP Antibody (860821) - MAB7164 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 860821
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Rat Anti-Human Lysosomal Pro‑X Carboxypeptidase/PRCP Monoclonal Antibody (Catalog # MAB7164) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for Lysosomal Pro‑X Carboxypeptidase/PRCP at approximately 55-60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Lysosomal Pro-X Carboxypeptidase/PRCP Antibody - AF7164 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Lysosomal Pro‑X Carboxypeptidase/PRCP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7164) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Lysosomal Pro‑X Carboxypeptidase/PRCP at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Lysosomal Pro-X Carboxypeptidase/PRCP Antibody - H00005547-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Lysosomal Pro-X Carboxypeptidase/PRCP Antibody [H00005547-B01P] - PRCP MaxPab polyclonal antibody. Western Blot analysis of PRCP expression in human kidney.

Lysosomal Pro-X Carboxypeptidase/PRCP Antibody - NBP1-81644 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PRCP Antibody [NBP1-81644] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-446
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