Gene Symbol | PRCP |
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Entrez Gene | 5547 |
Alt Symbol | HUMPCP, PCP |
Species | Human |
Gene Type | protein-coding |
Description | prolylcarboxypeptidase (angiotensinase C) |
Other Description | angiotensinase C|lysosomal Pro-X carboxypeptidase|lysosomal carboxypeptidase C|proline carboxypeptidase|prolylcarboxypeptidase isoform 1 preproprotein |
Swissprots | B3KRK5 P42785 B2R7B7 A8MU24 B5BU34 |
Accessions | EAW75074 EAW75075 EAW75076 P42785 AB451270 BAG70084 AB451397 BAG70211 AK090847 BAG52238 AK091786 BAG52417 AK302386 BAH13692 AK312919 BAG35764 BC001500 AAH01500 BI827978 BX537480 DB461615 DQ893068 ABM83994 DQ896321 ABM87320 L13977 AAA99891 XM_005274093 XP_005274150 NM_005040 NP_005031 NM_199418 NP_955450 |
Function | Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. |
Subcellular Location | Lysosome. |
Tissue Specificity | Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney. |
Top Pathways | Protein digestion and absorption |
Human PRCP full length protein - ab116920 from Abcam
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Human PRCP full length protein - ab159182 from Abcam
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Human PRCP full length protein - ab198658 from Abcam
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PRCP Antibody Blocking Peptide - LS-E2400 from LifeSpan Bioscience
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Recombinant Human Lysosomal Pro-X Carboxypeptidase/PRCP Protein - H00005547-P02 from Novus Biologicals
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Lysosomal Pro-X Carboxypeptidase/PRCP Recombinant Protein - H00005547-P01 from Novus Biologicals
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PRCP-Antibody-N-term-Blocking-peptide - BP13385a from Abgent, a WuXi AppTec company
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Recombinant Human PRCP, CF - 7164-SE-010 from R&D Systems
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PRCP / PCP - H00005547-P01-10 from Acris Antibodies
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PRCP / PCP - H00005547-P01-25 from Acris Antibodies
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PRCP / PCP - H00005547-P02 from Acris Antibodies
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PRCP / PCP - H00005547-P02-10 from Acris Antibodies
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PRCP / PCP - H00005547-P02-25 from Acris Antibodies
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PRCP fusion protein - Ag8869 from Proteintech Group
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PRCP fusion protein - Ag9095 from Proteintech Group
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PrCP, Active Human Recombinant Protein - GWB-PSC500 from Genway Biotech
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Recombinant Human PRCP - PRCP-31107TH from Creative Biomart
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Recombinant Human PRCP, GST-tagged - PRCP-1936H from Creative Biomart
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Recombinant Human PRCP, His-tagged - PRCP-23H from Creative Biomart
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Recombinant Prolylcarboxypeptidase (PRCP) - RPB253Hu01 from Uscn Life Science Inc.
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Recombinant Prolylcarboxypeptidase (PRCP) - RPB253Mu01 from Uscn Life Science Inc.
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Recombinant Prolylcarboxypeptidase (PRCP) - RPB253Ra01 from Uscn Life Science Inc.
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Recombinant Human Lysosomal Pro-X carboxypeptidase(PRCP) - CSB-YP018636HU CSB-EP018636HU CSB-BP018636HU CSB-MP018636HU from Cusabio
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Recombinant Human PRCP Protein, CF - 7164-SE from R&D Systems
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PRCP / PCP (N-term HIS tag, transcript variant 1) - TP760531 from Acris Antibodies
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