| Gene Symbol |
Tlr2
|
| Entrez Gene |
24088
|
| Alt Symbol |
Ly105
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
toll-like receptor 2
|
| Other Description |
-
|
| Swissprots |
Q9QUN7 Q9DBC4 Q3U400
|
| Accessions |
EDL15415 Q9QUN7 AF124741 AAD46481 AF165189 AAD49335 AF185284 AAF04277 AF216289 AAF28345 AK005043 BAB23770 AK154504 BAE32635 AY179346 AAO21125 BC014693 AAH14693 BP771904 BY743020 XM_006501460 XP_006501523 NM_011905 NP_036035
|
| Function |
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Detected in a macrophage cell line, smooth muscle, lung, spleen, thymus, brain and adipose tissue.
|
| Top Pathways |
Herpes simplex infection, Proteoglycans in cancer, Leishmaniasis, Inflammatory bowel disease (IBD), PI3K-Akt signaling pathway
|
![Western Blot: TLR2 Cell Lysate [NBP2-30165] - 15 ul of mouse TLR2 transfected cell lysate tested with IMG-526 (A) and IMG-662 (B).](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26125_TLR2-Cell-Lysate-Western-Blot-NBP2-30165-img0001.jpg)