Gene Symbol | Tlr2 |
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Entrez Gene | 24088 |
Alt Symbol | Ly105 |
Species | Mouse |
Gene Type | protein-coding |
Description | toll-like receptor 2 |
Other Description | - |
Swissprots | Q9QUN7 Q9DBC4 Q3U400 |
Accessions | EDL15415 Q9QUN7 AF124741 AAD46481 AF165189 AAD49335 AF185284 AAF04277 AF216289 AAF28345 AK005043 BAB23770 AK154504 BAE32635 AY179346 AAO21125 BC014693 AAH14693 BP771904 BY743020 XM_006501460 XP_006501523 NM_011905 NP_036035 |
Function | Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. |
Tissue Specificity | Detected in a macrophage cell line, smooth muscle, lung, spleen, thymus, brain and adipose tissue. |
Top Pathways | Herpes simplex infection, Proteoglycans in cancer, Leishmaniasis, Inflammatory bowel disease (IBD), PI3K-Akt signaling pathway |
TLR2 CRISPR/Cas9 KO Plasmid (m) - sc-423981 from Santa Cruz Biotechnology
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TLR2 HDR Plasmid (m) - sc-423981-HDR from Santa Cruz Biotechnology
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TLR2 Double Nickase Plasmid (m) - sc-423981-NIC from Santa Cruz Biotechnology
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TLR2 Double Nickase Plasmid (m2) - sc-423981-NIC-2 from Santa Cruz Biotechnology
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TLR2 CRISPR Activation Plasmid (m) - sc-423981-ACT from Santa Cruz Biotechnology
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TLR2 CRISPR Activation Plasmid (m2) - sc-423981-ACT-2 from Santa Cruz Biotechnology
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TLR2 Lentiviral Activation Particles (m) - sc-423981-LAC from Santa Cruz Biotechnology
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TLR2 Lentiviral Activation Particles (m2) - sc-423981-LAC-2 from Santa Cruz Biotechnology
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TLR2 siRNA (m) - sc-40257 from Santa Cruz Biotechnology
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TLR2 shRNA Plasmid (m) - sc-40257-SH from Santa Cruz Biotechnology
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TLR2 shRNA (m) Lentiviral Particles - sc-40257-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU010011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42895 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42895 from Sigma-Aldrich
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TLR2 siRNA (Mouse) - CRM4663 from Cohesion Biosciences
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TLR2 - MBS8202396 from MyBioSource
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shRNA set against Mouse TLR2 (NM_011905.3) - SHH427964 from Creative biogene
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shRNA set against Mouse Tlr2(NM_011905.3) - SHL072894 from Creative biogene
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Mouse TLR2 siRNA - orb284139 from Biorbyt
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TLR2 shRNA Plasmid (Mouse) - CHM4663 from Cohesion Biosciences
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TLR2 miRNA 3'UTR clone - MiUTR1M-11792 from Creative biogene
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