PCSK9

Gene Symbol	PCSK9
Entrez Gene	255738
Alt Symbol	FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Species	Human
Gene Type	protein-coding
Description	proprotein convertase subtilisin/kexin type 9
Other Description	convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1|subtilisin/kexin-like protease PC9
Swissprots	Q8NBP7 Q5PSM5 C0JYY9 Q5SZQ2 A8T640
Accessions	AAV67948 ACN81318 CAC38896 CAC60361 CDI44158 CDM55545 CDM55691 EAX06660 Q8NBP7 AK075365 BAC11572 AK122717 AK124635 BAC85910 AK293870 BAG57260 AK297473 BAG59894 BC042095 BC166619 AAI66619 DA738424 EF692496 ABV59216 XM_011541193 XP_011539495 NM_174936 NP_777596 NR_110451
Function	Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primaril
Subcellular Location	Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
Tissue Specificity	Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PCSK9 ELISA Kit (Sandwich ELISA) - LS-F2856 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 125-8000 pg/ml

Mouse PCSK9 ELISA Kit (Sandwich ELISA) - LS-F2857 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 62.5 pg/ml Range 125-8000 pg/ml

Human PCSK9 ELISA Kit (Sandwich ELISA) - LS-F717 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 125-8000 pg/ml

Human PCSK9 ELISA Kit (Sandwich ELISA) - LS-F7619 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.114 ng/ml Range 125-8000 pg/ml

Mouse PCSK9 ELISA Kit (Sandwich ELISA) - LS-F8053 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 6.4 pg/ml Range 125-8000 pg/ml

Rat PCSK9 ELISA Kit (Sandwich ELISA) - LS-F9168 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 3.13 ng/ml Range 125-8000 pg/ml

Rat PCSK9 ELISA Kit (Sandwich ELISA) - LS-F12275 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 125-8000 pg/ml

Proprotein Convertase 9/PCSK9 Assay Kit - KA1074 from Novus Biologicals Category Assay Kit Prices $1,429.00 Sizes 1 kit

Human Proprotein Convertase 9 Luminex Performance Assay - LUCA3888 from R&D Systems

Human Proprotein Convertase 9/PCSK9 Quantikine ELISA Kit - DPC900 from R&D Systems Category ELISA Kit Prices $519.00, $2,440.00, $17,646.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 0.219 ng/mL Range 0.6 - 40 ng/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma)

Human Proprotein Convertase 9/PCSK9 Quantikine PharmPak - PDPC900 from R&D Systems Category ELISA Kit

Human Proprotein Convertase 9/PCSK9 Quantikine SixPak - SPC900 from R&D Systems Category ELISA Kit Prices $2,440.00 Sizes 1 pack (6 Plates)

Mouse Proprotein Convertase 9/PCSK9 Quantikine ELISA Kit - MPC900 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 21.9 pg/mL Range 62.5 - 4,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma)

Human PCSK9/LDL R Complex DuoSet ELISA - DY5386 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 0.63 - 40 ng/mL

Human Proprotein Convertase 9/PCSK9 DuoSet ELISA - DY3888 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Mouse Proprotein Convertase 9 DuoSet ELISA - DY3985 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Quantikine Immunoassay Control Set 745 for Human PCSK9 - QC138 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

PCSK9 ELISA Kit (Human) : 96 Wells (OKAG00244) - OKAG00244 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 125 pg/mL Range 125-8,000 pg/mL

Human PCSK9 ELISA Kit - abx056305 from Abbexa Category ELISA Kit

Human PCSK9 ELISA Kit - abx152664 from Abbexa Category ELISA Kit Sensitivity 0.124 ng/ml Range 0.313 ng/ml - 20 ng/ml

Proprotein Convertase Subtilisin/Kexin Type 9, PCSK9, Human, ELISA Kit - E-EL-H1579 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Proprotein convertase subtilisin/kexin type 9 (PCSK9), Human, ELISA Kit - CSB-EL017647HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), Human, ELISA Kit - SEE189Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Proprotein Convertase Subtilisin/Kexin Type 9, Human, ELISA Kit - E01P0136 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Proprotein convertase subtilisin/kexin type 9, PCSK9, Human, ELISA Kit - E0307h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.312-20 ng/mL

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