PCSK9

Gene Symbol	PCSK9
Entrez Gene	255738
Alt Symbol	FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Species	Human
Gene Type	protein-coding
Description	proprotein convertase subtilisin/kexin type 9
Other Description	convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1|subtilisin/kexin-like protease PC9
Swissprots	Q8NBP7 Q5PSM5 C0JYY9 Q5SZQ2 A8T640
Accessions	AAV67948 ACN81318 CAC38896 CAC60361 CDI44158 CDM55545 CDM55691 EAX06660 Q8NBP7 AK075365 BAC11572 AK122717 AK124635 BAC85910 AK293870 BAG57260 AK297473 BAG59894 BC042095 BC166619 AAI66619 DA738424 EF692496 ABV59216 XM_011541193 XP_011539495 NM_174936 NP_777596 NR_110451
Function	Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primaril
Subcellular Location	Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
Tissue Specificity	Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PCSK9 full length protein - ab198471 from Abcam Category Protein Prices $1,281.00 Sizes 50 µg Source HEK 293 cells Species Human

Active mouse PCSK9 full length protein - ab167759 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Mouse

Human PCSK9 full length protein - ab155727 from Abcam Category Protein Source HEK 293 cells Species Human

Human PCSK9 full length protein - ab153779 from Abcam Category Protein Source HEK 293 cells Species Human

Human PCSK9 full length protein - ab155709 from Abcam Category Protein Source HEK 293 cells Species Human

Human PCSK9 full length protein - ab200507 from Abcam Category Protein Source HEK 293 cells Species Human

Human PCSK9 protein fragment - ab155736 from Abcam Category Protein Source HEK 293 cells Species Human

Mouse PCSK9 peptide - ab32727 from Abcam Category Peptide

PCSK9 peptide - ab44562 from Abcam Category Peptide

PCSK9 peptide - ab44583 from Abcam Category Peptide

PCSK9 peptide (679-692) - ab45712 from Abcam Category Peptide Species Human

Rat PCSK9 full length protein - ab201424 from Abcam Category Protein Source HEK 293 cells Species Rat

PCSK9 Antibody Blocking Peptide - LS-E8871 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCSK9 Antibody Blocking Peptide - LS-E8870 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCSK9 Antibody Blocking Peptide - LS-E26214 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCSK9 Antibody Blocking Peptide - LS-E25847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCSK9 Antibody Blocking Peptide - LS-E26967 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCSK9-Antibody-C-term-Blocking-Peptide - BP7333b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCSK9-Antibody-N-term-Blocking-Peptide - BP7333a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCSK9 blocking peptide - GTX47601-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Proprotein Convertase 9/PCSK9, CF - 3888-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg29-Gln152 & Ser153-Gln692, with a C-terminal 10-His tag

Mouse FH3 protein - orb83469 from Biorbyt Category Protein Prices $357.00, $527.00 Sizes 10 μg, 20 μg Source Mouse Species Human

Rhesus FH3 protein - orb83203 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human

Rat FH3 protein - orb83809 from Biorbyt Category Protein Prices $357.00, $527.00 Sizes 10 μg, 20 μg Source Rat Species Human

Human PCSK9 R protein - orb163425 from Biorbyt Category Protein Prices $323.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

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