PCSK9

Gene Symbol	PCSK9
Entrez Gene	255738
Alt Symbol	FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Species	Human
Gene Type	protein-coding
Description	proprotein convertase subtilisin/kexin type 9
Other Description	convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1|subtilisin/kexin-like protease PC9
Swissprots	Q8NBP7 Q5PSM5 C0JYY9 Q5SZQ2 A8T640
Accessions	AAV67948 ACN81318 CAC38896 CAC60361 CDI44158 CDM55545 CDM55691 EAX06660 Q8NBP7 AK075365 BAC11572 AK122717 AK124635 BAC85910 AK293870 BAG57260 AK297473 BAG59894 BC042095 BC166619 AAI66619 DA738424 EF692496 ABV59216 XM_011541193 XP_011539495 NM_174936 NP_777596 NR_110451
Function	Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primaril
Subcellular Location	Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
Tissue Specificity	Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PCSK9 overexpression lysate - LY403563 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PCSK9 293 Cell Lysate - 403079 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Proprotein Convertase 9/PCSK9 Overexpression Lysate (Native) - NBL1-14193 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PCSK9 Over-expression Lysate Product - GWB-7ED9AD from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Rhesus PCSK9 / NARC1 HEK293 Cell Lysate (WB positive control) - 11054-K08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Human PCSK9 / NARC1 HEK293 Cell Lysate (WB positive control) - 10594-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PCSK9 / NARC1 HEK293 Cell Lysate (WB positive control) - 10594-H08H1L-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human PCSK9 Human Cells Transfected Lysate (positive control) (denatured) - orb232830 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human PCSK9 Human Cells Transfected Lysate (positive control) (denatured) - orb172982 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

PCSK9-knockout Cell lysate - LC810408 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human PCSK9 Knockdown Stable Cell Line - CSC-DC011470 from Creative biogene Category Cell Line Species Human

Human PCSK9 Knockout Cell Line-HeLa - CSC-RT0735 from Creative biogene Category Cell Line Species Human

PCSK9 KO Cell Lysate-HeLa - CLKO-0239 from Creative biogene Category Cell Lysate

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