PCSK9

Gene Symbol PCSK9
Entrez Gene 255738
Alt Symbol FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Species Human
Gene Type protein-coding
Description proprotein convertase subtilisin/kexin type 9
Other Description convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1|subtilisin/kexin-like protease PC9
Swissprots Q8NBP7 Q5PSM5 C0JYY9 Q5SZQ2 A8T640
Accessions AAV67948 ACN81318 CAC38896 CAC60361 CDI44158 CDM55545 CDM55691 EAX06660 Q8NBP7 AK075365 BAC11572 AK122717 AK124635 BAC85910 AK293870 BAG57260 AK297473 BAG59894 BC042095 BC166619 AAI66619 DA738424 EF692496 ABV59216 XM_011541193 XP_011539495 NM_174936 NP_777596 NR_110451
Function Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primaril
Subcellular Location Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
Tissue Specificity Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

PCSK9 (H-160) - sc-66996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PCSK9 (H-160): sc-66996. Western blot analysis of PCSK9 expression in rat intestine tissue extract.

PCSK9 (C-12) - sc-34692 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PCSK9 (E-16) - sc-34693 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PCSK9 (E-16): sc-34693. Western blot analysis of PCSK9 expression in T84 (A), HCT 116 (B), SW480 (C), Hep G2 (D), MIA PaCa-2 (E) and SK-N-MC (F) whole cell lysates.

PCSK9 (N-12) - sc-34696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PCSK9 (N-12): sc-34696. Western blot analysis of PCSK9 expression in T84 (A) and HCT 116 (B) whole cell lysates.

Anti-PCSK9 antibody - ab28770 from Abcam

Prices $398.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
All lanes : Anti-PCSK9 antibody (ab28770) at 0.2 µg/mlLane 1 : untransfected McA cell lysate.Lane 2 : McA cell lysate transfected with wild type human PCSK9 Lane 3 : McA cell lysate transfected with S127R human PCSK9

Anti-PCSK9 antibody - ab125251 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PCSK9 antibody (ab125251) at 1/500 dilutionLane 1 : HT29 whole cell lysatesLane 2 : Mouse liver whole lysatesLane 3 : Mouse lung whole lysates

Anti-PCSK9 antibody - ab52754 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab52754 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab52754, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PCSK9 antibody - ab42085 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PCSK9 antibody (ab42085) at 1/1000 dilutionLane 1 : PCSK9 Protein at 0.08 µgLane 2 : Negative controlLane 3 : PCSK9 Protein at 0.04 µgLane 4 : Negative controlLane 5 : PCSK9 Protein at 0.02 µgLane 6 : Negative control at 0.08 µgLane 7 : PCSK9 Protein at 0.01 µg

Anti-PCSK9 antibody - ab42086 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PCSK9 antibody (ab42086) at 1/1000 dilutionLane 1 : PCSK9 Protein at 0.08 µgLane 2 : Negative controlLane 3 : PCSK9 Protein at 0.04 µgLane 4 : Negative controlLane 5 : PCSK9 Protein at 0.02 µgLane 6 : Negative controlLane 7 : PCSK9 Protein at 0.01 µg

Anti-PCSK9 antibody - ab52755 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PCSK9 antibody (ab52755) at 1/1000 dilutionLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-PCSK9 antibody - ab95478 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab95478 staining PCSK9 in HepG2 cells by immunofluorescence. The positive staining cytoplasm was visualized in red with a Cy3 conjugated goat anti-rabbit secondary antibody.

Anti-PCSK9 antibody [EPR7627(2)] - ab181142 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7627(2)
All lanes : Anti-PCSK9 antibody [EPR7627(2)] (ab181142) at 1/10000 dilutionLane 1 : A431 cell lysateLane 2 : HepG2 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-PCSK9 antibody [mAbcam84041] - ab84041 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam84041
All lanes : Anti-PCSK9 antibody [mAbcam84041] (ab84041) at 1/500 dilutionLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal Secondary Antibody to Mouse IgM (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PCSK9 antibody [MM088418D9] - ab201636 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM088418D9

Anti-PCSK9 antibody - BSA free - ab189449 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PCSK9 antibody - C-terminal - ab135648 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-PCSK9 antibody - C-terminal (ab135648) at 1/50 dilution + HeLa cell lysate at 35 µg

Anti-PCSK9 antibody - N-terminal - ab135647 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PCSK9 antibody - N-terminal (ab135647) at 1/100 dilution + Jurkat cell lysate at 35 µg

Anti-PCSK9 Antibody (aa35-694, clone 407119) - LS-C38393 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 407119

Anti-PCSK9 Antibody (aa490-502) - LS-C9764 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PCSK9 Antibody (aa214-228) - LS-C139568 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PCSK9 Antibody (aa164-175) - LS-C139574 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PCSK9 Antibody - LS-C146687 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal

Anti-PCSK9 Antibody (aa679-692) - LS-C148944 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-PCSK9 Antibody (C-Terminus) - LS-C155086 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PCSK9 Antibody (aa35-694, clone 407119) - LS-C170825 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 407119
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