Gene Symbol | PSMD11 |
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Entrez Gene | 5717 |
Alt Symbol | Rpn6, S9, p44.5 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
Other Description | 26S proteasome non-ATPase regulatory subunit 11|26S proteasome regulatory subunit 9|26S proteasome regulatory subunit RPN6|26S proteasome regulatory subunit S9|26S proteasome regulatory subunit p44.5 |
Swissprots | A8K3I7 E1P663 Q53FT5 O00231 O00495 |
Accessions | EAW80229 EAW80230 O00231 AB003102 BAA19748 AF001212 AAB58732 AK093602 AK223196 BAD96916 AK290602 BAF83291 AK300342 BAG62087 BC000437 AAH00437 BC004430 AAH04430 BP246240 BQ006240 NM_001270482 NP_001257411 NM_002815 NP_002806 |
Function | Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:22972301}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
Tissue Specificity | Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. {ECO:0000269|PubMed:22972301}. |
Top Pathways | Proteasome, Epstein-Barr virus infection |
PSMD11 (D1T1R) Rabbit mAb - 14303 from Cell Signaling Technology
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PSMD11 (H-297) - sc-367988 from Santa Cruz Biotechnology
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PSMD11 (P-20) - sc-79275 from Santa Cruz Biotechnology
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PSMD11 (O-23) - sc-133933 from Santa Cruz Biotechnology
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Anti-PSMD11 antibody [AT1F4] - ab89599 from Abcam
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Anti-PSMD11 Antibody (aa271-320) IHC-plus™ - LS-B11384 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (C-Terminus) IHC-plus™ - LS-B7777 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa405-423) - LS-C3300 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa406-423) - LS-C3301 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (clone AT1F4) - LS-C103489 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa1-422) - LS-C131661 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (Arg310) - LS-C192096 from LifeSpan Bioscience
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Anti-PSMD11 Antibody - LS-C211225 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (FITC) - LS-C211226 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (HRP) - LS-C211227 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (Biotin) - LS-C211229 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa175-225) - LS-C289462 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (N-Terminus) - LS-C80000 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa372-422) - LS-C289464 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa276-325) - LS-C31009 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (aa261-310) - LS-C200540 from LifeSpan Bioscience
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Anti-PSMD11 Antibody (N-Terminus) - LS-C109654 from LifeSpan Bioscience
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PSMD11 Antibody (1F4) - NBP1-30252 from Novus Biologicals
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PSMD11 Antibody - NBP1-46192 from Novus Biologicals
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PSMD11 Antibody - NBP1-46191 from Novus Biologicals
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