Gene Symbol | PSMD11 |
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Entrez Gene | 5717 |
Alt Symbol | Rpn6, S9, p44.5 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
Other Description | 26S proteasome non-ATPase regulatory subunit 11|26S proteasome regulatory subunit 9|26S proteasome regulatory subunit RPN6|26S proteasome regulatory subunit S9|26S proteasome regulatory subunit p44.5 |
Swissprots | A8K3I7 E1P663 Q53FT5 O00231 O00495 |
Accessions | EAW80229 EAW80230 O00231 AB003102 BAA19748 AF001212 AAB58732 AK093602 AK223196 BAD96916 AK290602 BAF83291 AK300342 BAG62087 BC000437 AAH00437 BC004430 AAH04430 BP246240 BQ006240 NM_001270482 NP_001257411 NM_002815 NP_002806 |
Function | Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:22972301}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. |
Tissue Specificity | Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. {ECO:0000269|PubMed:22972301}. |
Top Pathways | Proteasome, Epstein-Barr virus infection |
Human PSMD11 full length protein - ab159269 from Abcam
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Human PSMD11 full length protein - ab174394 from Abcam
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PSMD11 Antibody Blocking Peptide - LS-E7112 from LifeSpan Bioscience
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PSMD11 Antibody Blocking Peptide - LS-E11316 from LifeSpan Bioscience
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PSMD11 Antibody Blocking Peptide - LS-E11317 from LifeSpan Bioscience
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PSMD11 Recombinant Protein - H00005717-P01 from Novus Biologicals
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Recombinant Human PSMD11 Protein - NBP2-23372 from Novus Biologicals
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PSMD11-Antibody-C-term-Blocking-Peptide - BP2803b from Abgent, a WuXi AppTec company
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Recombinant human 26S proteasome non-ATPase regulatory subunit 11 protein (OPCA00339) - OPCA00339 from Aviva Systems Biology
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Human PSMD11 protein - orb245037 from Biorbyt
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PSMD11 (1-422, His-tag) - AR51290PU-N from Acris Antibodies
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PSMD11 (1-422, His-tag) - AR51290PU-S from Acris Antibodies
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PSMD11 - H00005717-P01-10 from Acris Antibodies
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PSMD11 - H00005717-P01-25 from Acris Antibodies
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PSMD11, 1-422aa, Human, His tag, E.coli - 01-P2470 from ARP American Research Products
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PSMD11 fusion protein - Ag6879 from Proteintech Group
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PSMD11 fusion protein - Ag6435 from Proteintech Group
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Recombinant human PSMD11, His-tagged - PSMD11-2470H from Creative Biomart
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Recombinant Human PSMD11, His-tagged - PSMD11-2027H from Creative Biomart
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PSMD11 (R310) Peptide - BS3780P from Bioworld Technology
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Recombinant human 26S proteasome non-ATPase regulatory subunit 11 protein - CSB-EP005754h CSB-BP005754h CSB-MP005754h from Cusabio
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Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein(PSMD11) - CSB-RP005754h from Cusabio
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Recombinant Human 26S proteasome non-ATPase regulatory subunit 11(PSMD11) - CSB-YP018901HU CSB-EP018901HU CSB-BP018901HU CSB-MP018901HU from Cusabio
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PSMD11, 1-422aa, Human, His tag, E.coli (Denatured) - ATGP2470 from ATGen
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26S proteasome non-ATPase regulatory subunit 11 protein - RPC140008 from Biomatik
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