| Gene Symbol |
PSMD11
|
| Entrez Gene |
5717
|
| Alt Symbol |
Rpn6, S9, p44.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
|
| Other Description |
26S proteasome non-ATPase regulatory subunit 11|26S proteasome regulatory subunit 9|26S proteasome regulatory subunit RPN6|26S proteasome regulatory subunit S9|26S proteasome regulatory subunit p44.5
|
| Swissprots |
A8K3I7 E1P663 Q53FT5 O00231 O00495
|
| Accessions |
EAW80229 EAW80230 O00231 AB003102 BAA19748 AF001212 AAB58732 AK093602 AK223196 BAD96916 AK290602 BAF83291 AK300342 BAG62087 BC000437 AAH00437 BC004430 AAH04430 BP246240 BQ006240 NM_001270482 NP_001257411 NM_002815 NP_002806
|
| Function |
Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:22972301}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. {ECO:0000269|PubMed:22972301}.
|
| Top Pathways |
Proteasome, Epstein-Barr virus infection
|
![Western Blot: PSMD11 Overexpression Lysate (Adult Normal) [NBL1-14896] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PSMD11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/18958_PSMD11%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14896-img0002.jpg)