| Gene Symbol |
IVNS1ABP
|
| Entrez Gene |
10625
|
| Alt Symbol |
FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
influenza virus NS1A binding protein
|
| Other Description |
NCX downstream gene 1|NS1-binding protein|aryl hydrocarbon receptor-associated 3|aryl hydrocarbon receptor-associated protein 3|influenza virus NS1A-binding protein|kelch-like family member 39
|
| Swissprots |
Q5TF75 Q9Y480 Q1G4T6 Q6NW38 Q1G4T7 Q9Y6Y0 Q9NZX0 Q7LCG2 A8K8R6
|
| Accessions |
EAW91193 EAW91194 Q9Y6Y0 AB020657 BAA74873 AF161553 AAF29040 AF205218 AAG43485 AJ012449 CAA10029 AK000931 AK001273 BAG50883 AK001625 AK001824 AK023020 BAG51150 AK023123 AK092912 AK093912 BAG52783 AK292431 BAF85120 AL137640 BC067739 AAH67739 BX648273 BX649183 CAE46201 DQ443528 ABE03889 DQ443529 ABE03890 XM_005244843 XP_005244900 XM_011509079 XP_011507381 XM_011509080 XP_011507382 XM_011509081 XP_011507383 NM_016389 NM_006469 NP_006460
|
| Function |
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.
|
| Top Pathways |
Influenza A
|
![Western Blot: NS1-BP Overexpression Lysate (Adult Normal) [NBL1-12089] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NS1-BP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8709_NS1-BP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12089-img0002.jpg)