IVNS1ABP

Gene Symbol	IVNS1ABP
Entrez Gene	10625
Alt Symbol	FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP
Species	Human
Gene Type	protein-coding
Description	influenza virus NS1A binding protein
Other Description	NCX downstream gene 1|NS1-binding protein|aryl hydrocarbon receptor-associated 3|aryl hydrocarbon receptor-associated protein 3|influenza virus NS1A-binding protein|kelch-like family member 39
Swissprots	Q5TF75 Q9Y480 Q1G4T6 Q6NW38 Q1G4T7 Q9Y6Y0 Q9NZX0 Q7LCG2 A8K8R6
Accessions	EAW91193 EAW91194 Q9Y6Y0 AB020657 BAA74873 AF161553 AAF29040 AF205218 AAG43485 AJ012449 CAA10029 AK000931 AK001273 BAG50883 AK001625 AK001824 AK023020 BAG51150 AK023123 AK092912 AK093912 BAG52783 AK292431 BAF85120 AL137640 BC067739 AAH67739 BX648273 BX649183 CAE46201 DQ443528 ABE03889 DQ443529 ABE03890 XM_005244843 XP_005244900 XM_011509079 XP_011507381 XM_011509080 XP_011507382 XM_011509081 XP_011507383 NM_016389 NM_006469 NP_006460
Function	Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.
Top Pathways	Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IVNS1ABP CRISPR/Cas9 KO Plasmid (h) - sc-409224 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP HDR Plasmid (h) - sc-409224-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP Double Nickase Plasmid (h) - sc-409224-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP Double Nickase Plasmid (h2) - sc-409224-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP CRISPR Activation Plasmid (h) - sc-409224-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP CRISPR Activation Plasmid (h2) - sc-409224-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP Lentiviral Activation Particles (h) - sc-409224-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP Lentiviral Activation Particles (h2) - sc-409224-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IVNS1ABP siRNA (h) - sc-75349 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IVNS1ABP shRNA Plasmid (h) - sc-75349-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IVNS1ABP shRNA (h) Lentiviral Particles - sc-75349-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU000031 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10847 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10847 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10175 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10175

IVNS1ABP siRNA (Human) - CRH7236 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IVNS1ABP, siRNA - MBS8217259 from MyBioSource Category siRNA Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IV (NM_006469.4) - SHH321765 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IVNS1ABP(NM_006469.4) - SHH137729 from Creative biogene Category siRNA Species Reactivities Human

Human IVNS1ABP siRNA - orb267738 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IVNS1ABP shRNA Plasmid (Human) - CHH7236 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

IVNS1ABP miRNA 3'UTR clone - MiUTR1H-05056 from Creative biogene Species Reactivities Human

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