IVNS1ABP

Gene Symbol IVNS1ABP
Entrez Gene 10625
Alt Symbol FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP
Species Human
Gene Type protein-coding
Description influenza virus NS1A binding protein
Other Description NCX downstream gene 1|NS1-binding protein|aryl hydrocarbon receptor-associated 3|aryl hydrocarbon receptor-associated protein 3|influenza virus NS1A-binding protein|kelch-like family member 39
Swissprots Q5TF75 Q9Y480 Q1G4T6 Q6NW38 Q1G4T7 Q9Y6Y0 Q9NZX0 Q7LCG2 A8K8R6
Accessions EAW91193 EAW91194 Q9Y6Y0 AB020657 BAA74873 AF161553 AAF29040 AF205218 AAG43485 AJ012449 CAA10029 AK000931 AK001273 BAG50883 AK001625 AK001824 AK023020 BAG51150 AK023123 AK092912 AK093912 BAG52783 AK292431 BAF85120 AL137640 BC067739 AAH67739 BX648273 BX649183 CAE46201 DQ443528 ABE03889 DQ443529 ABE03890 XM_005244843 XP_005244900 XM_011509079 XP_011507381 XM_011509080 XP_011507382 XM_011509081 XP_011507383 NM_016389 NM_006469 NP_006460
Function Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.
Top Pathways Influenza A

IVNS1ABP (C-17) - sc-69502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IVNS1ABP (C-17): sc-69502. Western blot analysis of IVNS1ABP expression in KNRK nuclear extract.

IVNS1ABP (G-9) - sc-373909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IVNS1ABP (G-9): sc-373909. Western blot analysis of IVNS1ABP expression in HeLa nuclear extract.

IVNS1ABP (H-300) - sc-98721 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IVNS1ABP (H-300): sc-98721. Western blot analysis of IVNS1ABP expression in HeLa nuclear extract.

IVNS1ABP (Q-18) - sc-69504 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IVNS1ABP (Q-18): sc-69504. Western blot analysis of IVNS1ABP expression in KNRK whole cell lysate.

IVNS1ABP (Y-17) - sc-69505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Influenza Virus NS1A Binding Protein antibody - ab127566 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Influenza Virus NS1A Binding Protein antibody (ab127566) at 1/1000 dilution + U-87 MG whole cell lysate at 30 µg

Anti-Influenza Virus NS1A Binding Protein antibody - ab22846 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Influenza Virus NS1A Binding Protein antibody (ab22846) at 2 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate (ab7900)

Anti-Influenza Virus NS1A Binding Protein antibody - ab101278 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Influenza Virus NS1A Binding Protein antibody (ab101278) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-IVNS1ABP / NS1-BP Antibody (aa47-96) - LS-C29945 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IVNS1ABP antibody LS-C29945 was used in IHC to stain formalin-fixed, paraffin-embedded human liver.

Anti-IVNS1ABP / NS1-BP Antibody (N-Terminus) - LS-C31721 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IVNS1ABP antibody LS-C31721 was used in IHC to stain formalin-fixed, paraffin-embedded human stomach.

Anti-IVNS1ABP / NS1-BP Antibody (aa50-100) - LS-C289590 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse NS1-BP by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug), and mouse NIH3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-NS1-BP antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. NS1-BP was also immunoprecipitated by rabbit anti-NS1-BP antibody BL10483, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

NS1-BP Antibody - NBP2-24567 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NS1-BP Antibody [NBP2-24567] - Analysis of Influenza A NS in a partial recombinant fusion protein containing amino acids DQKLGDAPFLDRLRRD using this antibody (1 ug/ml). Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

NS1-BP Antibody - NBP1-53044 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

NS1-BP Antibody - NBP1-83180 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NS1-BP Antibody - NBP2-19589 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NS1-BP Antibody [NBP2-19589] - Sample (30 ug of whole cell lysate) A: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000.

NS1-BP Antibody (4B1) - H00010625-M01-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B1

Anti-IVNS1ABP (AB1) antibody produced in rabbit - AV33099 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IVNS1ABP (ab1): <B>Cat. No. AV33099</B>: Immunohistochemistry of IVNS1ABP in Human Liver tissue with IVNS1ABP antibody at 4-8 μg/mL.

Anti-IVNS1ABP antibody produced in rabbit - HPA003405 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IVNS1ABP: <B>Cat. No. HPA003405</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing strong cytoplasmic staining of cells in distal tubules.

IVNS1ABP antibody - N-terminal region (ARP33099_P050) - ARP33099_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

IVNS1ABP antibody - N-terminal region (ARP33100_T100) - ARP33100_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Influenza NS1A binding protein antibody, N-term - GTX77835 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

IVNS1ABP antibody - GTX118817 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-IVNS1ABP antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX118817

IVNS1ABP antibody, N-term - GTX47777 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

Influenza Virus Ns1A Binding Protein antibody - 70R-2152 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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