IVNS1ABP

Gene Symbol IVNS1ABP
Entrez Gene 10625
Alt Symbol FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP
Species Human
Gene Type protein-coding
Description influenza virus NS1A binding protein
Other Description NCX downstream gene 1|NS1-binding protein|aryl hydrocarbon receptor-associated 3|aryl hydrocarbon receptor-associated protein 3|influenza virus NS1A-binding protein|kelch-like family member 39
Swissprots Q5TF75 Q9Y480 Q1G4T6 Q6NW38 Q1G4T7 Q9Y6Y0 Q9NZX0 Q7LCG2 A8K8R6
Accessions EAW91193 EAW91194 Q9Y6Y0 AB020657 BAA74873 AF161553 AAF29040 AF205218 AAG43485 AJ012449 CAA10029 AK000931 AK001273 BAG50883 AK001625 AK001824 AK023020 BAG51150 AK023123 AK092912 AK093912 BAG52783 AK292431 BAF85120 AL137640 BC067739 AAH67739 BX648273 BX649183 CAE46201 DQ443528 ABE03889 DQ443529 ABE03890 XM_005244843 XP_005244900 XM_011509079 XP_011507381 XM_011509080 XP_011507382 XM_011509081 XP_011507383 NM_016389 NM_006469 NP_006460
Function Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.
Top Pathways Influenza A

Human Influenza Virus NS1A Binding Protein protein fragment - ab161080 from Abcam

Category Protein
Source Wheat germ
Species Human
ab161080 on a 12.5% SDS-PAGE stained with Coomassie Blue.

IVNS1ABP / NS1-BP Antibody Blocking Peptide - LS-E11661 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human NS1-BP Protein - H00010625-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Influenza Virus Ns1A Binding Protein Blocking Peptide - 33R-7827 from Fitzgerald

Category Protein
Prices $130.00
Sizes 100 µg

IVNS1ABP - H00010625-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

IVNS1ABP - H00010625-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

IVNS1ABP fusion protein - ag6589 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

IVNS1ABP fusion protein - ag6412 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human Influenza virus NS1A-binding protein(IVNS1ABP) - CSB-YP896937HU CSB-EP896937HU CSB-BP896937HU CSB-MP896937HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

IVNS1ABP - TP309701 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
IVNS1ABP

Recombinant Human IVNS1ABP protein, His-tagged - IVNS1ABP-63H from Creative Biomart

Category Protein
Source E.coli
Species Human

NS1-BP Protein - NBP1-83180PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

IVNS1ABP Peptide, Human - M34GP07840H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Influenza virus NS1A-binding protein (IVNS1ABP), Recombinant Protein - MBS1477227 from MyBioSource

Category Protein
Prices $1,440.00, $1,440.00, $1,670.00, $1,670.00, $2,440.00, $2,440.00, $2,885.00, $2,885.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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