| Gene Symbol |
SPDEF
|
| Entrez Gene |
25803
|
| Alt Symbol |
PDEF, bA375E1.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SAM pointed domain containing ETS transcription factor
|
| Other Description |
SAM pointed domain-containing Ets transcription factor|prostate epithelium-specific Ets transcription factor|prostate-derived Ets factor|prostate-specific Ets
|
| Swissprots |
B4DWH8 O95238 F5H778
|
| Accessions |
CAC19002 CAC19004 CAC43877 CAI23605 EAX03788 O95238 AB031549 BAA89543 AF071538 AAC95296 AK301543 BAG63040 BC021299 AAH21299 EU446697 ABZ92226 EU832677 ACE87768 EU832757 ACE87089 XM_005248988 XP_005249045 XM_011514457 XP_011512759 NM_001252294 NP_001239223 NM_012391 NP_036523
|
| Function |
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells. {ECO:0000269|PubMed:10625666}.
|