| Gene Symbol |
EDF1
|
| Entrez Gene |
8721
|
| Alt Symbol |
EDF-1, MBF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endothelial differentiation-related factor 1
|
| Other Description |
multiprotein bridging factor 1
|
| Swissprots |
Q5T5T2 O60869 Q9UIM1
|
| Accessions |
CAJ42711 CBX85963 CBX85993 EAW88296 EAW88297 EAW88298 O60869 AA325420 AB002282 BAA88073 AB002283 BAA88074 BC015500 AAH15500 BI833652 BM800379 BQ279031 BT009863 AAP88865 CR541914 CAG46712 DQ891577 ABM82503 DQ894770 ABM85696 HY029111 HY086994 HY170122 NM_001281297 NP_001268226 NM_001281298 NP_001268227 NM_001281299 NP_001268228 NM_003792 NP_003783 NM_153200 NP_694880
|
| Function |
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
|
| Tissue Specificity |
Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:9813014}.
|