| Gene Symbol | AGO3 |
|---|---|
| Entrez Gene | 192669 |
| Alt Symbol | EIF2C3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | argonaute RISC catalytic component 3 |
| Other Description | argonaute 3|eukaryotic translation initiation factor 2C, 3|hAgo3|protein argonaute-3 |
| Swissprots | B1ALI0 Q5TA55 Q9H1U6 Q9H9G7 |
| Accessions | EAX07394 EAX07395 Q9H9G7 AA251146 AK022827 BAB14262 AK027796 BAB55374 AK292870 BAF85559 AK302289 BAG63629 AK303929 BAG64857 BC025769 BC066888 AAH66888 BC144409 BC156434 AAI56435 BC172480 AAI72480 BF438817 BF979526 BX104163 XM_005270575 XP_005270632 XM_005270576 XP_005270633 XM_011540879 XP_011539181 XM_011540880 XP_011539182 XM_011540881 XP_011539183 XM_011540882 XP_011539184 NM_024852 NP_079128 NM_177422 NP_803171 |
| Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. {ECO:0000255|HAMAP- Rule:MF_03032, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:23064648}. |
| Subcellular Location | Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03032, ECO:0000269|PubMed:16081698}. |