| Gene Symbol |
Tlr12
|
| Entrez Gene |
384059
|
| Alt Symbol |
Gm1365, Tlr11
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
toll-like receptor 12
|
| Other Description |
-
|
| Swissprots |
Q6QNU9
|
| Accessions |
EDL30230 Q6QNU9 AK137624 BAE23434 AK143385 BAE25360 AY510705 AAS37673 AY531552 AAS83531 BC131921 AAI31922 NM_205823 NP_991392
|
| Function |
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system. {ECO:0000250, ECO:0000269|PubMed:15001781}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Macrophages, liver, kidney and bladder epithelial cells. {ECO:0000269|PubMed:15001781}.
|
![Western Blot: Mouse TLR12 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line [NBP2-26288] - Analysis of TLR12 expression in the TLR12 reporter cell line using an HA antibody (20 ug total protein/lane). Legend. Cont: Control, NF-kB/SEAPorterTM HEK 293 cell line; TLR12: TLR12 reporter cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10764_Mouse-TLR12-NF-kB-SEAP---(SEAPorter(TM))-Stable-Reporter-Cell-Line-Western-Blot-NBP2-26288-img0010.jpg)
![Western Blot: Mouse TLR12 Stable Cell Line [NBP2-26287] - Analysis of TLR12 expression in the TLR12 stable cell line using an HA antibody (20 ug total protein/lane). Legend. Vect: Vector control stable cell line; TLR12: TLR12 stable cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10777_Mouse%2520TLR12%2520Stable%2520Cell%2520Line-Western%2520Blot-NBP2-26287-img0004.jpg)
![Western Blot: Mouse TLR11 Stable Cell Line [NBP2-26286] - Analysis of TLR11 expression in the TLR11 stable cell line using an HA antibody (20 ug total protein/lane). Legend. Vect: Vector control stable cell line; TLR11: TLR11 stable cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10779_Mouse%2520TLR11%2520Stable%2520Cell%2520Line-Western%2520Blot-NBP2-26286-img0004.jpg)