Gene Symbol |
SIGLEC6
|
Entrez Gene |
946
|
Alt Symbol |
CD327, CD33L, CD33L1, CD33L2, CDW327, OBBP1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
sialic acid binding Ig-like lectin 6
|
Other Description |
CD33 antigen-like 1|obesity-binding protein 1|sialic acid-binding Ig-like lectin 6
|
Swissprots |
B2RTS8 O15388 C9JBE5 A8MV71 O43700 O43699 F8WA78
|
Accessions |
AAK83655 EAW72024 EAW72025 EAW72026 EAW72027 O43699 AK300170 BAG61951 AK300182 BAG61961 AK308174 AK309903 AU138048 BC035359 AAH35359 BC140798 AAI40799 CA495365 D86358 BAA24983 D86359 BAA24984 U71382 AAB70702 XM_011527533 XP_011525835 XM_011527534 XP_011525836 XM_011527535 XP_011525837 XM_011527536 XP_011525838 XM_011527537 XP_011525839 XM_011527538 XP_011525840 XM_011527539 XP_011525841 XR_935876 XR_935877 NM_001177547 NP_001171018 NM_001177548 NP_001171019 NM_001177549 NP_001171020 NM_001245 NP_001236 NM_198845 NP_942142 NM_198846 NP_942143
|
Function |
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
|
Subcellular Location |
Isoform 1: Cell membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
|