| Gene Symbol |
APBA1
|
| Entrez Gene |
320
|
| Alt Symbol |
D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amyloid beta (A4) precursor protein-binding, family A, member 1
|
| Other Description |
adapter protein X11alpha|adaptor protein X11alpha|amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)|amyloid beta A4 precursor protein-binding family A member 1|mint-1|neuron-specific X11 protein|neuronal munc18-1-interacting protein 1|phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
|
| Swissprots |
Q02410 O14914 Q5VYR8 O60570
|
| Accessions |
EAW62486 EAW62487 Q02410 AF029106 AAC05304 AF047347 AAC39766 AL713639 BC156047 AAI56048 BC157030 AAI57031 BF435835 BQ269294 DA179202 DA313538 L04953 AAA61307 XM_005251968 XP_005252025 XM_006717093 XP_006717156 XM_011518617 XP_011516919 NM_001163 NP_001154
|
| Function |
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20531236}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20531236}. Nucleus {ECO:0000269|PubMed:20531236}. Note=Only about 5% of the protein is located in the nucleus.
|
| Tissue Specificity |
Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen. {ECO:0000269|PubMed:23737971}.
|