| Gene Symbol |
FBXO2
|
| Entrez Gene |
26232
|
| Alt Symbol |
FBG1, FBX2, Fbs1, NFB42, OCP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 2
|
| Other Description |
F-box gene 1|F-box only protein 2|organ of Corti protein 1
|
| Swissprots |
Q6FGJ7 Q9UK22 Q5TGY0 B2R7K7 Q8TB29 Q9UKC6
|
| Accessions |
EAW71689 Q9UK22 AF174594 AAF04515 AF187318 AAF01822 AK308531 AK313019 BAG35854 AW138262 AW162121 BC014957 BC025233 AAH25233 BC096747 AAH96747 BE464909 BF967195 BM128229 BP209877 CR542110 CAG46907 DQ892848 ABM83774 DQ892849 ABM83775 DQ896095 ABM87094 H18283 NM_012168 NP_036300
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|