| Gene Symbol | NKX2-2 |
|---|---|
| Entrez Gene | 4821 |
| Alt Symbol | NKX2.2, NKX2B |
| Species | Human |
| Gene Type | protein-coding |
| Description | NK2 homeobox 2 |
| Other Description | NK-2 homolog B|NK2 transcription factor related, locus 2|NK2 transcription factor-like protein B|homeobox protein NK-2 homolog B|homeobox protein Nkx-2.2 |
| Swissprots | O95096 |
| Accessions | AAC83132 AAG16976 EAX10183 O95096 BC075092 AAH75092 BC075093 AAH75093 BM314196 BQ632044 BU070383 CA772329 EU446641 ABZ92170 XM_006723566 XP_006723629 XM_011529237 XP_011527539 XR_937076 XR_937077 XR_937078 XR_937079 NM_002509 NP_002500 |
| Function | Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
| Top Pathways | Maturity onset diabetes of the young |
NK2 homeobox 2, ELISA Kit - MBS9331703 from MyBioSource
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Human NKX2-2 ELISA Kit - E026636 from Biobool
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anti-Nkx2.2 antibody [NX2/294] - ARG56172 from Arigo Biolaboratories
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