NKX2-2

Gene Symbol NKX2-2
Entrez Gene 4821
Alt Symbol NKX2.2, NKX2B
Species Human
Gene Type protein-coding
Description NK2 homeobox 2
Other Description NK-2 homolog B|NK2 transcription factor related, locus 2|NK2 transcription factor-like protein B|homeobox protein NK-2 homolog B|homeobox protein Nkx-2.2
Swissprots O95096
Accessions AAC83132 AAG16976 EAX10183 O95096 BC075092 AAH75092 BC075093 AAH75093 BM314196 BQ632044 BU070383 CA772329 EU446641 ABZ92170 XM_006723566 XP_006723629 XM_011529237 XP_011527539 XR_937076 XR_937077 XR_937078 XR_937079 NM_002509 NP_002500
Function Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Top Pathways Maturity onset diabetes of the young

Nkx-2.2 CRISPR/Cas9 KO Plasmid (h) - sc-401844 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 HDR Plasmid (h) - sc-401844-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 Double Nickase Plasmid (h) - sc-401844-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 Double Nickase Plasmid (h2) - sc-401844-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 CRISPR Activation Plasmid (h) - sc-401844-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 CRISPR Activation Plasmid (h2) - sc-401844-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 Lentiviral Activation Particles (h) - sc-401844-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 Lentiviral Activation Particles (h2) - sc-401844-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nkx-2.2 siRNA (h) - sc-38723 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nkx-2.2 shRNA Plasmid (h) - sc-38723-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nkx-2.2 shRNA (h) Lentiviral Particles - sc-38723-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NKX2.2 RNAi - H00004821-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU119891 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15330 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15330 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07189 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07189

NKX2-2 siRNA (Human) - CRH3201 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NKX2-2 shRNA Plasmid (Human) - CHH3201 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NKX2-2 miRNA 3'UTR clone - MiUTR3H-06957 from Creative biogene

Species Reactivities Human
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