| Gene Symbol |
PEA15
|
| Entrez Gene |
8682
|
| Alt Symbol |
HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoprotein enriched in astrocytes 15
|
| Other Description |
15 kDa phosphoprotein enriched in astrocytes|astrocytic phosphoprotein PEA-15|homolog of mouse MAT-1 oncogene|mammary transforming gene 1, mouse, homolog of|phosphoprotein enriched in diabetes
|
| Swissprots |
O00511 B1AKZ3 Q15121
|
| Accessions |
AAD56775 EAW52733 EAW52734 EAW52735 Q15121 AA837443 AI948916 AK095879 BAG53155 AK311762 BAG34705 BC002426 AAH02426 BC010469 AAH10469 BC022554 AAH22554 BT007252 AAP35916 CR541733 CAG46533 DA131259 DA157938 DA532423 DA538845 DA707281 DQ891821 ABM82747 DQ891824 ABM82750 DQ895008 ABM85934 HY182028 L37385 AAA98120 X86809 CAA60499 Y13736 CAA74076 XM_006711599 XP_006711662 NM_001297576 NP_001284505 NM_001297577 NP_001284506 NM_001297578 NP_001284507 NM_003768 NP_003759 NR_123724
|
| Function |
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}.
|
| Subcellular Location |
Cytoplasm. Note=Associated with microtubules.
|
| Tissue Specificity |
Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. {ECO:0000269|PubMed:9670003}.
|
