| Gene Symbol |
STX17
|
| Entrez Gene |
55014
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
syntaxin 17
|
| Other Description |
syntaxin-17
|
| Swissprots |
Q4VXC2 P56962
|
| Accessions |
EAW58920 P56962 AI375996 AK000658 BAA91311 AK095262 BAG53017 AK124662 AK295949 BAG58731 AK311412 AL833620 AL834371 CAD39034 BC051790 BC070269 AAH70269 BC101564 AAI01565 BC101566 AAI01567 BC111009 AAI11010 BC143430 DC318495 XM_011518820 XP_011517122 XM_011518821 XP_011517123 XM_011518822 XP_011517124 XM_011518823 XP_011517125 XR_929815 NM_017919 NP_060389
|
| Function |
SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol.
|
| Top Pathways |
SNARE interactions in vesicular transport
|