| Gene Symbol | STX17 |
|---|---|
| Entrez Gene | 55014 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | syntaxin 17 |
| Other Description | syntaxin-17 |
| Swissprots | Q4VXC2 P56962 |
| Accessions | EAW58920 P56962 AI375996 AK000658 BAA91311 AK095262 BAG53017 AK124662 AK295949 BAG58731 AK311412 AL833620 AL834371 CAD39034 BC051790 BC070269 AAH70269 BC101564 AAI01565 BC101566 AAI01567 BC111009 AAI11010 BC143430 DC318495 XM_011518820 XP_011517122 XM_011518821 XP_011517123 XM_011518822 XP_011517124 XM_011518823 XP_011517125 XR_929815 NM_017919 NP_060389 |
| Function | SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol. |
| Top Pathways | SNARE interactions in vesicular transport |
Syntaxin 17 CRISPR/Cas9 KO Plasmid (h) - sc-403251 from Santa Cruz Biotechnology
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Syntaxin 17 HDR Plasmid (h) - sc-403251-HDR from Santa Cruz Biotechnology
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Syntaxin 17 Double Nickase Plasmid (h) - sc-403251-NIC from Santa Cruz Biotechnology
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Syntaxin 17 Double Nickase Plasmid (h2) - sc-403251-NIC-2 from Santa Cruz Biotechnology
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Syntaxin 17 CRISPR Activation Plasmid (h) - sc-403251-ACT from Santa Cruz Biotechnology
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Syntaxin 17 CRISPR Activation Plasmid (h2) - sc-403251-ACT-2 from Santa Cruz Biotechnology
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Syntaxin 17 Lentiviral Activation Particles (h) - sc-403251-LAC from Santa Cruz Biotechnology
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Syntaxin 17 Lentiviral Activation Particles (h2) - sc-403251-LAC-2 from Santa Cruz Biotechnology
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Syntaxin 17 siRNA (h) - sc-92492 from Santa Cruz Biotechnology
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Syntaxin 17 shRNA Plasmid (h) - sc-92492-SH from Santa Cruz Biotechnology
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Syntaxin 17 shRNA (h) Lentiviral Particles - sc-92492-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20779 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20779 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09969 from Sigma-Aldrich
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STX17 siRNA (Human) - CRJ0407 from Cohesion Biosciences
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STX17 - MBS8223668 from MyBioSource
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shRNA set against Human STX17 (NM_017919.2) - SHH420280 from Creative biogene
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shRNA set against Human STX17(NM_017919.2) - SHL045584 from Creative biogene
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Human STX17 siRNA - orb270908 from Biorbyt
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STX17 shRNA Plasmid (Human) - CHJ0407 from Cohesion Biosciences
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STX17 miRNA 3'UTR clone - MiUTR1H-10035 from Creative biogene
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