| Gene Symbol |
ZIC2
|
| Entrez Gene |
7546
|
| Alt Symbol |
HPE5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Zic family member 2
|
| Other Description |
Zic family member 2 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 2|zinc finger protein ZIC 2
|
| Swissprots |
Q5VYA9 O95409 Q9H309
|
| Accessions |
EAX09030 EAX09031 O95409 AF104902 AAC96325 AF188733 AAG38995 AF193855 AAG28409 AF339806 BC172274 AAI72274 XM_011521110 XP_011519412 NM_007129 NP_009060
|
| Function |
Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). {ECO:0000250}.
|
| Top Pathways |
Hedgehog signaling pathway
|