ZIC2

Gene Symbol	ZIC2
Entrez Gene	7546
Alt Symbol	HPE5
Species	Human
Gene Type	protein-coding
Description	Zic family member 2
Other Description	Zic family member 2 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 2|zinc finger protein ZIC 2
Swissprots	Q5VYA9 O95409 Q9H309
Accessions	EAX09030 EAX09031 O95409 AF104902 AAC96325 AF188733 AAG38995 AF193855 AAG28409 AF339806 BC172274 AAI72274 XM_011521110 XP_011519412 NM_007129 NP_009060
Function	Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). {ECO:0000250}.
Top Pathways	Hedgehog signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ZIC2 Antibody Blocking Peptide - LS-E27643 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZIC2 Antibody Blocking Peptide - LS-E12743 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZIC2 Peptide - AC21-2461-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ZIC2 Peptide - 42-349P from ProSci Category Peptide Species Human

Recombinant Human Zinc finger protein ZIC 2(ZIC2) - CSB-YP026485HU CSB-EP026485HU CSB-BP026485HU CSB-MP026485HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ZIC2 - TP320798 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Zinc finger protein ZIC 2 (ZIC2) , Recombinant Protein - MBS1234494 from MyBioSource Category Protein Prices $2,185.00, $2,185.00, $2,650.00, $2,650.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZIC2, Peptide - MBS427665 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

ZIC2 Peptide, Human - M34GP17830H from Creative Peptides Category Peptide Source Synthetic. Species Human

Zic2 Recombinant Protein Antigen - NBP2-55066PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZIC2 Immunizing peptide - orb66235 from Biorbyt Category Peptide

Recombinant Human ZIC2 Protein, MYC/DDK-tagged - ZIC2-439H from Creative Biomart Category Protein Source HEK293 Species Human

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