ZIC2

Gene Symbol ZIC2
Entrez Gene 7546
Alt Symbol HPE5
Species Human
Gene Type protein-coding
Description Zic family member 2
Other Description Zic family member 2 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 2|zinc finger protein ZIC 2
Swissprots Q5VYA9 O95409 Q9H309
Accessions EAX09030 EAX09031 O95409 AF104902 AAC96325 AF188733 AAG38995 AF193855 AAG28409 AF339806 BC172274 AAI72274 XM_011521110 XP_011519412 NM_007129 NP_009060
Function Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). {ECO:0000250}.
Top Pathways Hedgehog signaling pathway

Zic2 CRISPR/Cas9 KO Plasmid (h) - sc-404720 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 HDR Plasmid (h) - sc-404720-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 Double Nickase Plasmid (h) - sc-404720-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 Double Nickase Plasmid (h2) - sc-404720-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 CRISPR Activation Plasmid (h) - sc-404720-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 CRISPR Activation Plasmid (h2) - sc-404720-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 Lentiviral Activation Particles (h) - sc-404720-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 Lentiviral Activation Particles (h2) - sc-404720-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zic2 siRNA (h) - sc-45881 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Zic2 shRNA Plasmid (h) - sc-45881-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Zic2 shRNA (h) Lentiviral Particles - sc-45881-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Zic2 RNAi - H00007546-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN23219 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23219 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12447 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12447

ZIC2 siRNA (Human) - CRH5157 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZIC2 - MBS8238517 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human ZIC2 siRNA - orb265659 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZIC2 shRNA Plasmid (Human) - CHH5157 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ZIC2 miRNA 3'UTR clone - MiUTR3H-05632 from Creative biogene

Species Reactivities Human
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