ZIC2

Gene Symbol ZIC2
Entrez Gene 7546
Alt Symbol HPE5
Species Human
Gene Type protein-coding
Description Zic family member 2
Other Description Zic family member 2 (odd-paired homolog, Drosophila)|Zinc finger protein of the cerebellum 2|zinc finger protein ZIC 2
Swissprots Q5VYA9 O95409 Q9H309
Accessions EAX09030 EAX09031 O95409 AF104902 AAC96325 AF188733 AAG38995 AF193855 AAG28409 AF339806 BC172274 AAI72274 XM_011521110 XP_011519412 NM_007129 NP_009060
Function Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). {ECO:0000250}.
Top Pathways Hedgehog signaling pathway

Zic2 (C-14) - sc-28153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zic2 (C-14): sc-28153. Western blot analysis of Zic2 expression in NIH/3T3 nuclear extract.

Zic2 (H-40) - sc-367002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Zic2 (H-40): sc-367002. Western blot analysis of Zic2 expression in mouse brain tissue extract.

Zic2 (L-15) - sc-28152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Zic2 (N-13) - sc-28151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Zic2 antibody - ab61278 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Zic2 antibody - ab187330 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Zic2 antibody (ab187330) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-Zic2 antibody [EPR7790] - ab150404 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7790
Overlay histogram showing SH-SY5Y cells stained with ab150404 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab150404, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-ZIC2 Antibody (aa190-207) - LS-C91431 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZIC2 Antibody (aa189-206) - LS-C132985 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZIC2 Antibody (clone 3C12) - LS-C198454 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C12

Anti-ZIC2 Antibody (aa350-400) - LS-C148698 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ZIC2 in HepG2 cell lysate using 1) pre-bleed, and 2) LS-C148698 at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-ZIC2 Antibody (aa520-531) - LS-C154839 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ZIC2 antibody RWPE1 lysate (60 ug protein in RIPA buffer) overexpressing Human ZIC2 with C-terminal MYC tag probed with (0.5 ug/ml) in the right panel and probed with anti-MYC Tag (1/1000) and anti-beta-Actin in the left panel. Mock-transfected RWPE1 in lanes 1 and expressing GFP in lanes 2. Primary incubations were overnight at 4C. Detected by chemiluminescence.

Anti-ZIC2 Antibody (aa189-206) - LS-C19096 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ZIC2 Antibody - Western Blot. Western blot of Affinity Purified anti-ZIC2 antibody shows detection of a band ~55 kD (arrowhead) corresponding to ZIC2 in lysates from (lane 1) mouse brain and (lane 2) rat brain. Approximately 20 ug of each lysate was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-ZIC2 antibody. Signal was detected using standard techniques. The upper band in the mouse brain lysate represents Zic2.

Anti-ZIC2 Antibody (aa446-495) - LS-C30460 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ZIC2 antibody LS-C30460 was used in IHC to stain formalin-fixed, paraffin-embedded human skin.

Zic2 Antibody - NBP2-24607 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Zic2 Antibody [NBP2-24607] - Analysis of ZIC2 in HepG2 cell lysate using 1) pre-bleed, and 2) this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Zic2 Antibody - NBP2-27506 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Zic2 Antibody (4A7) - H00007546-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A7

Zic2 Antibody (3G5) - H00007546-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G5

Zic2 Antibody (3C12) - H00007546-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C12

Zic2 Antibody (3H7) - H00007546-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H7

Zic2 Polyclonal Antibody - bs-11610R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Zic2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11610R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Zic2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11610R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Zic2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11610R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Zic2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11610R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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