TNK1

Gene Symbol TNK1
Entrez Gene 8711
Alt Symbol -
Species Human
Gene Type protein-coding
Description tyrosine kinase, non-receptor, 1
Other Description CD38 negative kinase 1|non-receptor tyrosine-protein kinase TNK1
Swissprots O95364 Q8IYI4 Q13470
Accessions AAC99412 CCQ43245 EAW90203 EAW90204 Q13470 AI810287 AK225403 AK310684 AK311063 BC035782 AAH35782 DA089305 DB287365 DQ891230 ABM82156 DQ894414 ABM85340 U43408 AAC50427 XM_011524045 XP_011522347 XM_011524046 XP_011522348 XM_011524047 XP_011522349 XM_011524048 XP_011522350 NM_001251902 NP_001238831 NM_003985 NP_003976
Function Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10873601}. Membrane {ECO:0000269|PubMed:10873601}; Peripheral membrane protein {ECO:0000269|PubMed:10873601}.
Tissue Specificity Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:8632913}.

Phospho-TNK1 (Tyr277) Antibody - 4553 from Cell Signaling Technology

Prices $279.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from L-540 cells using Phospho-TNK1 (Tyr277) Antibody (upper and middle) or TNK1 (C44F9) Rabbit mAb #4570 (lower). The middle membrane was treated with calf intestinal alkaline phosphatase (CIP) before antibody probing. L-540 cells express a 58 kDa TNK1-C17orf61 fusion protein containing 466 amino acids from the amino terminus of TNK1 [Gu, T.L. et al. (2010) Leukemia, in press]. TNK1 kinase was constitutively activated in these cells.

Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb - 5638 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D46E7
Western blot analysis of extracts from L-540 cells, untreated or pre-incubated with either a site-specific phosphorylated peptide to block the signal or a site-specific non-phosphorylated peptide, using Phospho-TNK1 (Tyr277) (D46E7) Rabbit mAb. L-540 cells express a 58 kDa TNK1-C17orf61 fusion protein containing 466 amino acids from the amino terminus of TNK1 [Gu, T.L. et al. (2010) Leukemia ].

TNK1 (C44F9) Rabbit mAb - 4570 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C44F9
Western blot analysis of extracts from HCT-116 cells using TNK1 (C44F9) Rabbit mAb.

TNK1 (H-11) - sc-390359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TNK1 (H-11): sc-390359. Western blot analysis of TNK1 expression in HUV-EC-C (A), HEL 92.1.7 (B), T-47D (C) and PC-3 (D) whole cell lysates.

TNK1 (N-15) - sc-165758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TNK1 (H-53) - sc-292008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TNK1 (C-13) - sc-101869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

TNK1 (V-20) - sc-165759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Tnk1 antibody - ab102984 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Tnk1 antibody (ab102984) at 1/100 dilution + T47D cell line lysate at 35 µg

Anti-Tnk1 antibody - ab130998 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Tnk1 antibody (ab130998) at 1 µg/ml + RPMI-8226 cell lysate at 10 µg

Anti-Tnk1 antibody [3F11H6] - ab70402 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F11H6
All lanes : Anti-Tnk1 antibody [3F11H6] (ab70402) at 1/500 dilutionLane 1 : Molecular weight markersLane 2 : Truncated Tnk1-His recombinant protein

Anti-TNK1 Antibody (aa517-566) IHC-plus™ - LS-B11489 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TNK1 antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11489 concentration 10 ug/ml.

Anti-TNK1 Antibody (aa421-434) - LS-C40722 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNK1 Antibody - LS-C83395 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNK1 Antibody (phospho-Tyr277, clone D46E7) - LS-C184140 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone D46E7

Anti-CD38 Antibody (clone 11J26) - LS-C182740 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 11J26

Anti-TNK1 Antibody (clone 170CT7.5.4, AP) - LS-C212537 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 170CT7.5.4

Anti-TNK1 Antibody (clone 170CT7.5.4, APC) - LS-C212538 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 170CT7.5.4

Anti-TNK1 Antibody (clone 170CT7.5.4, Biotin) - LS-C212539 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 170CT7.5.4

Anti-TNK1 Antibody (clone 170CT7.5.4, FITC) - LS-C212540 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 170CT7.5.4

Anti-TNK1 Antibody (clone 170CT7.5.4, PE) - LS-C212542 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 170CT7.5.4

Anti-TNK1 Antibody (clone 170CT7.5.4, Azide-free, HRP) - LS-C212541 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 170CT7.5.4

Anti-TNK1 Antibody (AP) - LS-C218030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNK1 Antibody (APC) - LS-C218031 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNK1 Antibody (Biotin) - LS-C218032 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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