| Gene Symbol |
TNK1
|
| Entrez Gene |
8711
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tyrosine kinase, non-receptor, 1
|
| Other Description |
CD38 negative kinase 1|non-receptor tyrosine-protein kinase TNK1
|
| Swissprots |
O95364 Q8IYI4 Q13470
|
| Accessions |
AAC99412 CCQ43245 EAW90203 EAW90204 Q13470 AI810287 AK225403 AK310684 AK311063 BC035782 AAH35782 DA089305 DB287365 DQ891230 ABM82156 DQ894414 ABM85340 U43408 AAC50427 XM_011524045 XP_011522347 XM_011524046 XP_011522348 XM_011524047 XP_011522349 XM_011524048 XP_011522350 NM_001251902 NP_001238831 NM_003985 NP_003976
|
| Function |
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10873601}. Membrane {ECO:0000269|PubMed:10873601}; Peripheral membrane protein {ECO:0000269|PubMed:10873601}.
|
| Tissue Specificity |
Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:8632913}.
|