| Gene Symbol |
NSDHL
|
| Entrez Gene |
50814
|
| Alt Symbol |
H105E3, SDR31E1, XAP104
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NAD(P) dependent steroid dehydrogenase-like
|
| Other Description |
protein H105e3|short chain dehydrogenase/reductase family 31E, member 1|sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
|
| Swissprots |
O00344 D3DWT6 Q15738
|
| Accessions |
EAW72897 EAW72898 EAW72899 Q15738 AK026549 AM393176 CAL38054 AM393670 CAL38546 BC000245 AAH00245 BC007816 AAH07816 DQ892488 ABM83414 DQ895699 ABM86625 U47105 AAC50558 XM_011531178 XP_011529480 NM_001129765 NP_001123237 NM_015922 NP_057006
|
| Function |
Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. {ECO:0000269|PubMed:14506130}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506130}; Single-pass membrane protein {ECO:0000269|PubMed:14506130}. Lipid droplet {ECO:0000269|PubMed:14506130}. Note=Trafficking through the Golgi is necessary for ER membrane localization.
|
| Tissue Specificity |
Brain, heart, liver, lung, kidney, skin and placenta.
|
| Top Pathways |
Steroid biosynthesis
|