Gene Symbol | NSDHL |
---|---|
Entrez Gene | 50814 |
Alt Symbol | H105E3, SDR31E1, XAP104 |
Species | Human |
Gene Type | protein-coding |
Description | NAD(P) dependent steroid dehydrogenase-like |
Other Description | protein H105e3|short chain dehydrogenase/reductase family 31E, member 1|sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |
Swissprots | O00344 D3DWT6 Q15738 |
Accessions | EAW72897 EAW72898 EAW72899 Q15738 AK026549 AM393176 CAL38054 AM393670 CAL38546 BC000245 AAH00245 BC007816 AAH07816 DQ892488 ABM83414 DQ895699 ABM86625 U47105 AAC50558 XM_011531178 XP_011529480 NM_001129765 NP_001123237 NM_015922 NP_057006 |
Function | Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. {ECO:0000269|PubMed:14506130}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506130}; Single-pass membrane protein {ECO:0000269|PubMed:14506130}. Lipid droplet {ECO:0000269|PubMed:14506130}. Note=Trafficking through the Golgi is necessary for ER membrane localization. |
Tissue Specificity | Brain, heart, liver, lung, kidney, skin and placenta. |
Top Pathways | Steroid biosynthesis |