| Gene Symbol |
PCGF1
|
| Entrez Gene |
84759
|
| Alt Symbol |
2010002K04Rik, NSPC1, RNF3A-2, RNF68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polycomb group ring finger 1
|
| Other Description |
RING finger protein 68|nervous system Polycomb-1|polycomb group RING finger protein 1
|
| Swissprots |
Q7Z506 Q9BSM1
|
| Accessions |
EAW99632 EAW99633 Q9BSM1 AF087884 AAP97183 AK125742 AL049296 BC004952 AAH04952 BU602498 HQ447406 ADQ31892 XM_005264618 XP_005264675 NM_032673 NP_116062
|
| Function |
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering c
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:21282530}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:11287196}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|