PCGF1

Gene Symbol PCGF1
Entrez Gene 84759
Alt Symbol 2010002K04Rik, NSPC1, RNF3A-2, RNF68
Species Human
Gene Type protein-coding
Description polycomb group ring finger 1
Other Description RING finger protein 68|nervous system Polycomb-1|polycomb group RING finger protein 1
Swissprots Q7Z506 Q9BSM1
Accessions EAW99632 EAW99633 Q9BSM1 AF087884 AAP97183 AK125742 AL049296 BC004952 AAH04952 BU602498 HQ447406 ADQ31892 XM_005264618 XP_005264675 NM_032673 NP_116062
Function Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering c
Subcellular Location Nucleus {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:21282530}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:11287196}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

PCGF1 CRISPR/Cas9 KO Plasmid (h) - sc-407339 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 HDR Plasmid (h) - sc-407339-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 Double Nickase Plasmid (h) - sc-407339-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 Double Nickase Plasmid (h2) - sc-407339-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 CRISPR Activation Plasmid (h) - sc-407339-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 CRISPR Activation Plasmid (h2) - sc-407339-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 Lentiviral Activation Particles (h) - sc-407339-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 Lentiviral Activation Particles (h2) - sc-407339-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PCGF1 siRNA (h) - sc-94353 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCGF1 shRNA Plasmid (h) - sc-94353-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PCGF1 shRNA (h) Lentiviral Particles - sc-94353-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU003901 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16471 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16471 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PCGF1 siRNA (Human) - CRJ3612 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PCGF1 RNAi - H00084759-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PCGF1 (NM_032673.2) - SHH371808 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PCGF1(NM_032673.2) - SHR096592 from Creative biogene

Category siRNA
Species Reactivities Human

PCGF1 shRNA Plasmid (Human) - CHJ3612 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PCGF1 miRNA 3'UTR clone - MiUTR1H-07659 from Creative biogene

Species Reactivities Human
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