PCGF1

Gene Symbol	PCGF1
Entrez Gene	84759
Alt Symbol	2010002K04Rik, NSPC1, RNF3A-2, RNF68
Species	Human
Gene Type	protein-coding
Description	polycomb group ring finger 1
Other Description	RING finger protein 68|nervous system Polycomb-1|polycomb group RING finger protein 1
Swissprots	Q7Z506 Q9BSM1
Accessions	EAW99632 EAW99633 Q9BSM1 AF087884 AAP97183 AK125742 AL049296 BC004952 AAH04952 BU602498 HQ447406 ADQ31892 XM_005264618 XP_005264675 NM_032673 NP_116062
Function	Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering c
Subcellular Location	Nucleus {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:21282530}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:11287196}.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PCGF1 protein fragment - ab132882 from Abcam Category Protein Source Wheat germ Species Human

Human PCGF1 protein fragment - ab164655 from Abcam Category Protein Source Wheat germ Species Human

PCGF1 peptide - ab94828 from Abcam Category Peptide

NSPC1 / PCGF1 Antibody Blocking Peptide - LS-E15955 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PCGF1 Protein - H00084759-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PCGF1 Protein - H00084759-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PCGF1 Blocking Peptide - 33R-6967 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PCGF1 / RNF68 - H00084759-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PCGF1 / RNF68 - H00084759-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PCGF1 / RNF68 - H00084759-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PCGF1 / RNF68 - H00084759-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PCGF1 fusion protein - Ag9264 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PCGF1 fusion protein - ag7983 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PCGF1, His-tagged - PCGF1-1574H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Polycomb group RING finger protein 1(PCGF1) - CSB-YP863114HU CSB-EP863114HU CSB-BP863114HU CSB-MP863114HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PCGF1 Protein - abx164020 from Abbexa Category Protein Species Human, Mouse

Polycomb group RING finger protein 1 (PCGF1), Recombinant Protein - MBS1396537 from MyBioSource Category Protein Prices $1,010.00, $1,010.00, $1,240.00, $1,240.00, $1,550.00, $1,550.00, $2,015.00, $2,015.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PCGF1 Recombinant Protein Antigen - NBP1-82767PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PCGF1-Blocking-Peptide-Center - BP20960a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCGF1-Blocking-Peptide-Center - BP21270c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCGF1 Peptide, Human - M34GP11438H from Creative Peptides Category Peptide Source Synthetic. Species Human

PCGF1 Recombinant Protein Antigen - NBP2-55951PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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