A2M

Gene Symbol	A2M
Entrez Gene	2
Alt Symbol	A2MD, CPAMD5, FWP007, S863-7
Species	Human
Gene Type	protein-coding
Description	alpha-2-macroglobulin
Other Description	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|alpha-2-M
Swissprots	Q13677 Q68DN2 P01023 Q59F47 Q5QTS0 Q6PN97 Q6PIY3
Accessions	AAK38109 AAK38110 CAA48670 CAA77774 CCO13665 EAW88590 P01023 AB209614 BAD92851 AK307832 AK312482 AY591530 AAT02228 BC026246 AAH26246 BC040071 AAH40071 BX504041 BX647329 BX648622 CR749334 CAH18188 M11313 AAA51551 M36501 AAA51552 XM_006719056 XP_006719119 NM_000014 NP_000005
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Location	Secreted {ECO:0000269|PubMed:6203908}.
Tissue Specificity	Secreted in plasma. {ECO:0000269|PubMed:6203908}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

alpha 2 Macroglobulin Human ELISA Kit - ab108888 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 1 µg/ml Range 1.25 µg/ml - 40 µg/ml

alpha 2 Macroglobulin Human ELISA Kit - ab108883 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 2 ng/ml Range 0.002 µg/ml - 0.5 µg/ml

Human A2M / Alpha-2-Macroglobulin ELISA Kit (Sandwich ELISA) - LS-F2835 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 20 pg/ml Range 625-40000 pg/ml

Human A2M / Alpha-2-Macroglobulin ELISA Kit (Sandwich ELISA) - LS-F4392 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.78 ng/ml Range 625-40000 pg/ml

Mouse A2M / Alpha-2-Macroglobulin ELISA Kit (Competitive EIA) - LS-F6496 from LifeSpan Bioscience Category ELISA Kit Prices $520.00 Sizes 1 plate Sensitivity 2.97 ng/ml Range 625-40000 pg/ml

Rat A2M / Alpha-2-Macroglobulin EIA Kit - LS-F6423 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 2.68 ng/ml Range 6.17 - 500 ng/ml

Human A2M / Alpha-2-Macroglobulin ELISA Kit (Sandwich ELISA) - LS-F10409 from LifeSpan Bioscience Category ELISA Kit Prices $480.00 Sizes 1 plate Sensitivity 0.2 ng/ml Range 625-40000 pg/ml

Bovine A2M / Alpha-2-Macroglobulin ELISA Kit (Sandwich ELISA) - LS-F10697 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 3.12 Range 625-40000 pg/ml

Human A2M / Alpha-2-Macroglobulin ELISA Kit (Sandwich ELISA) - LS-F9539 from LifeSpan Bioscience Category ELISA Kit Prices $640.00 Sizes 1 plate Sensitivity 19.2 pg/ml Range 625-40000 pg/ml

Human A2M / Alpha-2-macroglobulin ELISA Kit - RAB0600 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

A2M/ 2-Macroglobulin BioAssay™ ELISA Kit, Human - 143702 from USBiological Life Science Category ELISA Kit Sensitivity < 20 pg/ml Range 625pg/ml-40,000pg/ml

Human alpha 2-Macroglobulin DuoSet ELISA - DY1938 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 0.63 - 40 ng/mL

alpha 2 Macroglobulin ELISA kit - 55R-1887 from Fitzgerald Category ELISA Kit Prices $495.00 Sizes 1 kit

Human a2M ELISA Kit - abx150489 from Abbexa Category ELISA Kit Sensitivity 5.1 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Human A2M ELISA Kit - abx056000 from Abbexa Category ELISA Kit

Human Alpha-2-Macroglobulin ELISA Kit - abx150623 from Abbexa Category ELISA Kit Sensitivity 0.39 ng/ml Range 0.781 ng/ml - 50 ng/ml

Alpha-2 Macroglobulin, a2-M, Human, ELISA Kit - E-EL-H0967 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

Alpha-2-Macroglobulin (a2M), Human, ELISA Kit - SEB017Hu from ARP American Research Products Category ELISA Kit Prices $580.00 Sizes 96 t Sensitivity 0.31ng/mL Range 0.78 -50ng/mL

Alpha-2-macroglobulin, A2M, Human, ELISA Kit - E1017h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 7.8-500 ng/mL

Alpha2 macroglobulin, alpha2 MG, Human, ELISA Kit - CSB-E08959h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 50 ng/ml Range 100 ng/ml-5000ng/ml

High Sensitive Alpha-2-Macroglobulin (a2M), Human, ELISA Kit - HEB017Hu from ARP American Research Products Category ELISA Kit Prices $644.00 Sizes 96 t Sensitivity 5.1pg/mL Range 15.6-1,000pg/mL

A2M (Human) IP-WB Antibody Pair - H00000002-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

A2M (Human) ELISA kit - KA0486 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

A2M (Human) ELISA kit - KA0487 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human Alpha 2-M ELISA - ELH-A2M from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 4 ng/ml Range 4 ng/ml - 3,000 ng/ml

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