A2M

Gene Symbol	A2M
Entrez Gene	2
Alt Symbol	A2MD, CPAMD5, FWP007, S863-7
Species	Human
Gene Type	protein-coding
Description	alpha-2-macroglobulin
Other Description	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|alpha-2-M
Swissprots	Q13677 Q68DN2 P01023 Q59F47 Q5QTS0 Q6PN97 Q6PIY3
Accessions	AAK38109 AAK38110 CAA48670 CAA77774 CCO13665 EAW88590 P01023 AB209614 BAD92851 AK307832 AK312482 AY591530 AAT02228 BC026246 AAH26246 BC040071 AAH40071 BX504041 BX647329 BX648622 CR749334 CAH18188 M11313 AAA51551 M36501 AAA51552 XM_006719056 XP_006719119 NM_000014 NP_000005
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Location	Secreted {ECO:0000269|PubMed:6203908}.
Tissue Specificity	Secreted in plasma. {ECO:0000269|PubMed:6203908}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human alpha 2 Macroglobulin full length protein - ab77935 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Human alpha 2 Macroglobulin full length protein - ab167796 from Abcam Category Protein Prices $285.00 Sizes 1 mg Source Native Species Human

Human alpha 2 Macroglobulin full length protein - ab91104 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Human alpha 2 Macroglobulin peptide - ab93750 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human alpha 2 Macroglobulin protein fragment - ab157817 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

A2M / Alpha-2-Macroglobulin Antibody Blocking Peptide - LS-E3588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

A2M / Alpha-2-Macroglobulin Antibody Blocking Peptide - LS-E3589 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

A2M / Alpha-2-Macroglobulin Antibody Blocking Peptide - LS-E21658 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

alpha 2-Macroglobulin Partial Recombinant Protein - H00000002-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

alpha 2-Macroglobulin Human Expressed Protein - P4913 from Novus Biologicals Category Protein Prices $549.00 Sizes 1 mg Species Human

A2M-Antibody-C-term-Blocking-Peptide - BP14790b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

A2M-Antibody-N-term-Blocking-Peptide - BP14789a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human alpha 2-Macroglobulin, CF - 1938-PI-050 from R&D Systems Category Protein Source Human plasma-derived

Human Alpha 2 Macroglobulin Protein (OPMA04241) - OPMA04241 from Aviva Systems Biology Category Protein Prices $150.00 Sizes 1 mg Source Human Plasma Species Human

A2M Protein (OPPA01428) - OPPA01428 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 200 µg Source Human Plasma

NATIVE Human ALPHA 2 MACROGLOBULIN Protein (OPSA10557) - OPSA10557 from Aviva Systems Biology Category Protein Prices $355.00 Sizes 1 mg Species Human

Human Alpha 2 Macroglobulin protein - orb82119 from Biorbyt Category Protein Prices $255.00 Sizes 1 mg Source Sample obtained from Human. Species Human

Human alpha 2 Macroglobulin protein - orb80896 from Biorbyt Category Protein Prices $170.00, $289.00, $961.00 Sizes 200 μg, 1 mg, 10 mg Species Human

Human alpha 2 Macroglobulin His tag protein - orb84368 from Biorbyt Category Protein Prices $417.00, $748.00 Sizes 20 μg, 50 μg Source Insect Species Human

Alpha 2 Macroglobulin protein - 30-1040 from Fitzgerald Category Protein Prices $195.00 Sizes 1 mg Species Human

alpha 2 Macroglobulin protein - 30R-AM036 from Fitzgerald Category Protein Prices $242.00 Sizes 1 mg

alpha 2 Macroglobulin protein - 30C-CP3005 from Fitzgerald Category Protein Prices $154.80 Sizes 1 mg

A2M Blocking Peptide - abx161243 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Human Alpha-2-Macroglobulin Protein - abx065251 from Abbexa Category Protein Source E.coli Species Human

Alpha-2-macroglobulin / A2M - AR05066PU-N from Acris Antibodies Category Protein Prices $350.00 Sizes 1 mg Source Human Species Human

Search more