A2M

Gene Symbol	A2M
Entrez Gene	2
Alt Symbol	A2MD, CPAMD5, FWP007, S863-7
Species	Human
Gene Type	protein-coding
Description	alpha-2-macroglobulin
Other Description	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|alpha-2-M
Swissprots	Q13677 Q68DN2 P01023 Q59F47 Q5QTS0 Q6PN97 Q6PIY3
Accessions	AAK38109 AAK38110 CAA48670 CAA77774 CCO13665 EAW88590 P01023 AB209614 BAD92851 AK307832 AK312482 AY591530 AAT02228 BC026246 AAH26246 BC040071 AAH40071 BX504041 BX647329 BX648622 CR749334 CAH18188 M11313 AAA51551 M36501 AAA51552 XM_006719056 XP_006719119 NM_000014 NP_000005
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Location	Secreted {ECO:0000269|PubMed:6203908}.
Tissue Specificity	Secreted in plasma. {ECO:0000269|PubMed:6203908}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

A2M 293T Cell Transient Overexpression Lysate(Denatured) - H00000002-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

A2M overexpression lysate - LY424975 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

A2M 293 Cell Lysate - 410350 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

alpha 2-Macroglobulin Overexpression Lysate (Denatured) - H00000002-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

alpha 2-Macroglobulin Overexpression Lysate (Native) - NBL1-07157 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

α-2M (h): 293T Lysate - sc-115474 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

A2M Over-expression Lysate Product - GWB-C4A0D2 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human A2M / CPAMD5 / Alpha-2-macroglobulin Insect Cell Lysate (WB positive control) - 10952-H08BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Panoply™ Human A2M Knockdown Stable Cell Line - CSC-DC000002 from Creative biogene Category Cell Line Species Human

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