NAMPT

Gene Symbol	NAMPT
Entrez Gene	10135
Alt Symbol	1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Species	Human
Gene Type	protein-coding
Description	nicotinamide phosphoribosyltransferase
Other Description	NAmPRTase|pre-B cell-enhancing factor|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1
Swissprots	P43490 A4D0Q9 Q3KQV0 A4D0R0 Q8WW95
Accessions	AAF19249 AAQ96862 CAM12699 CAN36300 CAV30744 CBX74360 CBX78820 EAL24399 EAL24400 EAW83382 EAW83383 EAW83384 P43490 AI299587 AK023341 AK292851 BAF85540 AK304085 BAH14102 AL832518 CAH56351 BC020691 BC072439 AAH72439 BC106046 AAI06047 BI859562 HQ447548 ADQ32034 L29050 U02020 AAA17884 XM_005250100 XP_005250157 XM_011515707 XP_011514009 NM_005746 NP_005737 NM_182790
Function	Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
Tissue Specificity	Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NAMPT / Visfatin ELISA Kit (Sandwich ELISA) - LS-F4383 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 0.1-1000 ng/ml

Rat NAMPT / Visfatin ELISA Kit (Sandwich ELISA) - LS-F4384 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 0.1-1000 ng/ml

Mouse NAMPT / Visfatin ELISA Kit (Sandwich ELISA) - LS-F4385 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 31.2 pg/ml Range 0.1-1000 ng/ml

Bovine NAMPT / Visfatin ELISA Kit (Sandwich ELISA) - LS-F6081 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 1.27 ng/ml Range 0.1-1000 ng/ml

Mouse/Human/Rat NAMPT / Visfatin ELISA Kit (Competitive EIA) - LS-F418 from LifeSpan Bioscience Category ELISA Kit Prices $440.00, $820.00, $1,900.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.1 ng/ml Range 0.1-1000 ng/ml

Guinea pig NAMPT / Visfatin ELISA Kit (Sandwich ELISA) - LS-F9319 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.52 ng/ml Range 0.1-1000 ng/ml

Visfatin EIA Kit - RAB0377 from Sigma-Aldrich Prices $399.50 Sizes 1 kt

Human PBEF/Visfatin DuoSet ELISA - DY4335-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 0.50 - 32 ng/mL

Visfatin ELISA Kit - 55R-1414 from Fitzgerald Category ELISA Kit Prices $909.00 Sizes 100 assays

Visfatin ELISA Kit (Mouse/Rat) - 55R-1415 from Fitzgerald Category ELISA Kit Prices $895.00 Sizes 100 assays

Nicotinamide phosphoribosyltransferase (NAMPT), Human, ELISA Kit - E01N0539 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Nicotinamide phosphoribosyltransferase, NAMPT, Human, ELISA Kit - E0638h from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t Range 1.56-100 ng/mL

Visfatin, VF, Human, ELISA Kit - E-EL-H1763 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Visfatin (VF), Human, ELISA Kit - SEA638Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 6.3pg/mL Range 15.6-1,000pg/mL

Visfatin, Human, ELISA Kit - CSB-E08940h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.156 ng/ml Range 0.625 ng/ml-40 ng/ml

Visfatin, Human, ELISA Kit - E01V0003 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Visfatin, Human, ELISA Kit - YHB3195Hu from ARP American Research Products Category ELISA Kit

Visfatin, VF, Mouse, ELISA Kit - E-EL-M1237 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Visfatin, VF, Rat, ELISA Kit - E-EL-R1067 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Visfatin, VF, Rabbit, ELISA Kit - E-EL-RB2252 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Visfatin, VF, Chicken, ELISA Kit - E-EL-Ch0480 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Visfatin, VF, Porcine, ELISA Kit - E-EL-P0333 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Visfatin, VF, Guinea Pig, ELISA Kit - E-EL-GP0230 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Visfatin, VF, Monkey, ELISA Kit - E-EL-MK0606 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

NAMPT/Nampt (Human, Mouse, Rat) ELISA Kit - KA1865 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Search more